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I-TASSER QUARK LOMETS COACH COFACTOR MUSTER SEGMER FG-MD ModRefiner REMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom EvoDesign GPCR-I-TASSER

TM-score TM-align MMalign NWalign EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW CASP7 CASP8 CASP9 CASP10 CASP11

Yang Zhang's Research Group

We are interested in:
I-TASSER model vs crystal structure of T0604_1, a CASP9 FM target
Determining structure and function of protein molecules is a cornerstone of modern biology and medicine. One of the main focuses of our lab is to develop computational methods to predict 3-dimensional structure of protein molecules from amino acid sequence, and to deduce the biological functions based on the sequence-to-structure-to-function paradigm. The second focus of our lab is to combine computational algorithms and biochemistry experiments to design new protein molecules with enhanced functionality that nature proteins could not achieve. We are also working on modeling ligand-protein and protein-protein interactions, with particular interest in new drug screening targeting the human G protein-coupled receptors ( >> read more ... ).

Job opening
  • Postdoctoral position in protein design: We are in search of postdoc candidates who are interested in protein design and have web-lab experience on protein engineering and structure determination ( >> read more ... ).
  • Postdoctoral position in protein structure prediction: We seek for talent and creative postdoc candidates who are interested in developing the best computer algorithms for protein folding and protein structure prediction ( >> read more ... ).

yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue Ann Arbor, MI 48109-2218