BindProf is a method for predicting free energy changes (ΔΔG) of protein-protein binding
interactions upon mutations of residues at the interface. While BindProf adopts a multi-scale
approach using multiple sources of information at different levels of
structural resolution, a unique feature of BindProf
is the inclusion of an interface structural profile score derived from multiple
structure alignments from analogous protein-protein interactions
(>> read more about BindProf ...).
Note: This server is only for dimeric complexes currently with
mutations at one side of the interface
scores for each feature for the SKEMPI database of mutations of protein complexes.
final 10-fold cross-validated model constructed using only the structural profiles and sequence dependent terms.
model constructed using the structural profiles, sequence dependent terms, and C-Beta terms.
model constructed with all terms including those requiring a full atom model.
- J R Brender, Y Zhang.
Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles,
PLoS Comput Biol. 2015 Oct 27;11(10):e1004494. doi: 10.1371/journal.pcbi.1004494.