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BindProf is a method for predicting free energy changes (ΔΔG) of protein-protein binding interactions upon mutations of residues at the interface. While BindProf adopts a multi-scale approach using multiple sources of information at different levels of structural resolution, a unique feature of BindProf is the inclusion of an interface structural profile score derived from multiple structure alignments from analogous protein-protein interactions (>> read more about BindProf ...).


BindProf On-line

Note: This server is only for dimeric complexes currently with mutations at one side of the interface

  • Input Structure in PDB format (mandatory):
    Please copy and paste your structure file here. Sample input

    Or upload the stucture file:


  • Please input a list of mutations (one per mutation set per line with multiple mutations set out off by semicolons, WT residue followed by the chain of the mutation followed by the mutated residue. Examples
      YA180A; -Single mutation Tyr180 on Chain A is mutated to Ala
      YA180A;WA24C; -Double mutations on the same chain Tyr180 on Chain A is mutated to Ala and Trp24 is mutated to Cys)
    Sample input

  • Input Email: (optional, where results will be sent to)


  • Downloadable resources

    References:

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