BioLiP is updated weekly (every Friday) and the current version (Feb 17, 2017) contains:
Number of entries: 369,770
Number of proteins from PDB: 79,557
Number of DNA/RNA ligands: 43,328
Number of peptide ligands: 17,814
Number of metal ligands: 104,778
Number of regular ligands: 203,850
Number of entries with binding affinity data: 23,492
(10,971 from Binding MOAD, 16,980 from PDBbind-CN, 7,331 from BindingDB, and 64 from manual survey of the original literature)
The ocurence frequency of all ligands in BioLiP.
Current version: Feb 17, 2017 with 369,770 entries.
2014-09-10: The ocurence frequency of all ligands in BioLiP was provided on the ligand information page.
2014-09-10: A Perl script (download_all_sets.pl) was provided for automatic download of all the weekly updated subsets.
2013-08-19: A link was added at the search and browse pages to allow users to export searching results in CSV format.
2013-03-15: BioLiP was rebuilt with the following changes: (1) All DNA/RNA-protein interactions from PDB were added, which should be useful for studying Nucleic Acids-protein interactions. In previous versions, only small DNA/RNA ligands were considered. (2) The k-mer ligand "UUU" was divided into component ligands and removed from the database.
2012-12-14: BioLiP was updated with 211,382 entries. 102 ligands were added to the artifact ligand list, which helped us reduce about 1000 false positive entries.
2012-12-07: BioLiP was updated with 211,819 entries. 642 false postive entries for the ligands RG1 and IMD were manually removed.
2012-11-30: BioLiP was updated with 212,148 entries. The COACH algorithm was redesigned and is available at here.
2012-11-16: BioLiP was updated with 211,040 entries. 233 false postive entries for the ligands FTT and MYR were manually removed.
2012-11-09: BioLiP was updated with 210,894 entries. The number of BioLiP entries with binding affinity data was increased from 20127 to 22091 with the latest realse of the PDBbind-CN database.
2012-11-02: BioLiP was updated with 210,377 entries. 108 false postive entries for the ligands TRD and UND were manually removed.
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