1hqf A 2.9 BS01 MN A 1 H101 D124 D128 D232 H96 D119 D123 D227 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0002376,0004053,0005615,0005634,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 500 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqf A 2.9 BS02 MN A 2 D124 H126 D232 D234 D119 H121 D227 D229 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0002376,0004053,0005615,0005634,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 501 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqf A 2.9 BS03 HAR A 1 D124 H126 D128 H141 E186 D232 D234 E277 D119 H121 D123 H136 E181 D227 D229 E272 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0002376,0004053,0005615,0005634,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 -logKd/Ki=5.00, Ki=10uM P07824 11258880 906 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqf B 2.9 BS01 MN B 1 H101 D124 D128 D232 H96 D119 D123 D227 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0002376,0004053,0005615,0005634,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 502 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqf B 2.9 BS02 MN B 2 D124 H126 D232 D234 D119 H121 D227 D229 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0002376,0004053,0005615,0005634,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 503 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqf B 2.9 BS03 HAR B 1 D124 H126 D128 H141 E186 D232 D234 E277 D119 H121 D123 H136 E181 D227 D229 E272 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0002376,0004053,0005615,0005634,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 907 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqf C 2.9 BS01 MN C 1 H101 D124 D128 D232 H96 D119 D123 D227 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0002376,0004053,0005615,0005634,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 504 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqf C 2.9 BS02 MN C 2 D124 H126 D232 D234 D119 H121 D227 D229 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0002376,0004053,0005615,0005634,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 505 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL 1hqf C 2.9 BS03 HAR C 1 D124 H126 D128 H141 E186 D232 D234 E277 D119 H121 D123 H136 E181 D227 D229 E272 H101 D124 H126 D128 H141 D232 D234 E277 H96 D119 H121 D123 H136 D227 D229 E272 3.5.3.1 0000050,0001889,0001938,0002250,0002376,0004053,0005615,0005634,0005737,0005741,0005829,0006525,0007565,0009410,0009635,0010042,0010043,0010269,0014075,0016787,0016813,0019547,0030145,0030324,0032496,0032964,0033189,0033197,0042130,0042802,0042832,0043025,0043200,0043434,0045087,0046007,0046686,0046872,0048545,0048678,0051597,0060056,0060135,0060336,0070301,0070965,0071222,0071353,0071377,0071549,0071560,1905541,2000552 P07824 11258880 908 KPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYL