3bzu A 2.25 BS01 NAP A 1 G41 S43 K44 G45 I46 R66 S67 T92 M93 N119 H120 I121 V168 S170 Y183 K187 L215 L217 I218 T220 T222 A223 G17 S19 K20 G21 I22 R42 S43 T68 M69 N95 H96 I97 V144 S146 Y159 K163 L191 L193 I194 T196 T198 A199 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18069989 1 EEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSYNMD 3bzu A 2.25 BS02 A21 A 1 T124 L171 A172 V180 Y183 L217 M233 T100 L147 A148 V156 Y159 L193 M209 S170 Y183 K187 S146 Y159 K163 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=14nM Ki=22nM P28845 18069989 293 EEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTSYNMD 3bzu B 2.25 BS01 NAP B 1 G41 S43 K44 G45 I46 R66 S67 T92 M93 N119 H120 I121 V168 S170 Y183 K187 L215 G216 L217 I218 T220 T222 A223 G20 S22 K23 G24 I25 R45 S46 T71 M72 N98 H99 I100 V147 S149 Y162 K166 L194 G195 L196 I197 T199 T201 A202 S170 Y183 K187 S149 Y162 K166 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18069989 2 PLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTS 3bzu B 2.25 BS02 A21 B 1 T124 L126 L171 A172 Y177 Y183 L217 T103 L105 L150 A151 Y156 Y162 L196 S170 Y183 K187 S149 Y162 K166 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=14nM Ki=22nM P28845 18069989 293 PLNEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYSTS 3bzu C 2.25 BS01 NAP C 1 G41 S43 K44 G45 I46 A65 R66 S67 T92 M93 N119 I121 V168 S170 Y183 K187 L215 G216 L217 I218 T220 T222 A223 G18 S20 K21 G22 I23 A42 R43 S44 T69 M70 N96 I98 V145 S147 Y160 K164 L192 G193 L194 I195 T197 T199 A200 S170 Y183 K187 S147 Y160 K164 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18069989 3 NEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYST 3bzu C 2.25 BS02 A21 C 1 L171 A172 Y183 G216 L217 A223 L148 A149 Y160 G193 L194 A200 S170 Y183 K187 S147 Y160 K164 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=14nM Ki=22nM P28845 18069989 293 NEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYST 3bzu D 2.25 BS01 NAP D 1 G41 S43 K44 G45 I46 R66 T92 M93 N119 I121 V168 S170 Y183 K187 L215 L217 I218 T220 T222 A223 G16 S18 K19 G20 I21 R41 T65 M66 N92 I94 V141 S143 Y156 K160 L188 L190 I191 T193 T195 A196 S170 Y183 K187 S143 Y156 K160 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 P28845 18069989 4 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS 3bzu D 2.25 BS02 A21 D 1 T124 L171 A172 Y183 L217 M233 T97 L144 A145 Y156 L190 M206 S170 Y183 K187 S143 Y156 K160 1.1.1.146,1.1.1.201 0005496,0005783,0005789,0006706,0008202,0016020,0016491,0030324,0042803,0043231,0047022,0050661,0070524,0102196 ic50=14nM Ki=22nM P28845 18069989 293 EFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPSRKILEFLYS