3mle A 2.8 BS01 MG A 1 T14 D50 E116 T16 D52 E118 T9 N10 K13 T14 K35 T39 D50 E116 T11 N12 K15 T16 K37 T41 D52 E118 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 222 GHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle A 2.8 BS02 8AC A 1 G151 I153 N154 G153 I155 N156 T9 N10 K13 T14 K35 T39 D50 E116 T11 N12 K15 T16 K37 T41 D52 E118 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 225 GHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle A 2.8 BS03 ADP A 1 N10 A11 G12 K13 T14 T15 N175 N12 A13 G14 K15 T16 T17 N177 T9 N10 K13 T14 K35 T39 D50 E116 T11 N12 K15 T16 K37 T41 D52 E118 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 -logKd/Ki=5.24, Kd=5.8uM O24872 22284390 226 GHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle A 2.8 BS04 8AC C 1 T39 S79 A80 V123 T41 S81 A82 V125 T9 N10 K13 T14 K35 T39 D50 E116 T11 N12 K15 T16 K37 T41 D52 E118 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 224 GHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle B 2.8 BS01 MG B 1 T14 D50 E116 T18 D54 E120 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 222 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKGS 3mle B 2.8 BS02 8AC B 1 G151 I153 N154 G155 I157 N158 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 225 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKGS 3mle B 2.8 BS03 ADP B 1 N10 G12 K13 T14 T15 E116 N175 N14 G16 K17 T18 T19 E120 N179 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 226 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKGS 3mle B 2.8 BS04 8AC D 1 T39 V123 T43 V127 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 224 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKGS 3mle C 2.8 BS01 8AC A 1 T39 S79 T43 S83 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 225 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle C 2.8 BS02 MG C 1 T14 D50 E116 T18 D54 E120 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 222 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle C 2.8 BS03 8AC C 1 G151 I153 N154 G155 I157 N158 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 224 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle C 2.8 BS04 ADP C 1 N10 A11 G12 K13 T14 T15 N175 K177 N14 A15 G16 K17 T18 T19 N179 K181 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 225 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle D 2.8 BS01 8AC B 1 T39 A80 T43 A84 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 225 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle D 2.8 BS02 MG D 1 T14 D50 E116 T18 D54 E120 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 222 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle D 2.8 BS03 8AC D 1 G151 I153 N154 G155 I157 N158 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 224 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle D 2.8 BS04 ADP D 1 N10 G12 K13 T14 T15 N175 K177 N14 G16 K17 T18 T19 N179 K181 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 225 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle E 2.8 BS01 MG E 1 T14 D50 E116 T16 D52 E118 T9 N10 K13 T14 K35 T39 D50 E116 T11 N12 K15 T16 K37 T41 D52 E118 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 222 GHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle E 2.8 BS02 ADP E 1 N10 A11 G12 K13 T14 T15 N175 K177 N12 A13 G14 K15 T16 T17 N177 K179 T9 N10 K13 T14 K35 T39 D50 E116 T11 N12 K15 T16 K37 T41 D52 E118 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 223 GHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle E 2.8 BS03 8AC E 1 L150 G151 I153 N154 L152 G153 I155 N156 T9 N10 K13 T14 K35 T39 D50 E116 T11 N12 K15 T16 K37 T41 D52 E118 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 224 GHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle F 2.8 BS01 8AC E 1 T39 G119 V123 T43 G123 V127 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 224 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle F 2.8 BS02 MG F 1 T14 D50 E116 T18 D54 E120 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 222 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle F 2.8 BS03 8AC F 1 L150 G151 I153 L154 G155 I157 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 225 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG 3mle F 2.8 BS04 ADP F 1 N10 A11 G12 K13 T14 T15 N175 K177 N14 A15 G16 K17 T18 T19 N179 K181 T9 N10 K13 T14 K35 T39 D50 E116 T13 N14 K17 T18 K39 T43 D54 E120 6.3.3.3 0000166,0000287,0004141,0005524,0005737,0005829,0009102,0016874,0046872 O24872 22284390 226 FQGHMLFISATNTNAGKTTCARLLAQYCNACGVKTILLKPIETGVNDAINHSSDAHLFLQDNRLLDRSLTLKDISFYRYHKVSAPLIAQQEEDPNAPIDTDNLTQRLHNFTKTYDLVIVEGAGGLCVPITLEENMLDFALKLKAKMLLISHDNLGLINDCLLNDFLLKSHQLDYKIAINLKGNNTAFHSISLPYIELFNTRSNNPIVIFQQSLKVLMSFALKG