3mss A 1.95 BS01 STI A 1 L248 Y253 A269 K271 E286 M290 I313 T315 F317 M318 I360 H361 A380 D381 F382 L21 Y26 A42 K44 E53 M57 I80 T82 F84 M85 I127 H128 A147 D148 F149 D363 A365 R367 N368 D381 P402 D130 A132 R134 N135 D148 P168 2.7.10.2 0004672,0004713,0005524,0006468 IC50=10.8nM P00520 20450175 1 MDPSYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 3mss A 1.95 BS02 MS7 A 1 L341 A433 P465 V468 L108 A199 P231 V234 D363 A365 R367 N368 D381 P402 D130 A132 R134 N135 D148 P168 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=4.66, Kd=22uM P00520 20450175 516 MDPSYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 3mss B 1.95 BS01 STI B 1 L248 Y253 A269 K271 E286 M290 I313 T315 F317 M318 I360 H361 L370 A380 D381 F382 L21 Y26 A42 K44 E53 M57 I80 T82 F84 M85 I127 H128 L137 A147 D148 F149 D363 A365 R367 N368 D381 P402 D130 A132 R134 N135 D148 P168 2.7.10.2 0004672,0004713,0005524,0006468 IC50=10.8nM P00520 20450175 1 MDPSYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 3mss B 1.95 BS02 MS7 B 1 L341 A433 P465 L108 A199 P231 D363 A365 R367 N368 D381 P402 D130 A132 R134 N135 D148 P168 2.7.10.2 0004672,0004713,0005524,0006468 P00520 20450175 516 MDPSYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 3mss C 1.95 BS01 STI C 1 L248 Y253 A269 K271 E286 M290 I293 I313 T315 F317 M318 I360 H361 A380 D381 F382 L21 Y26 A42 K44 E53 M57 I60 I80 T82 F84 M85 I127 H128 A147 D148 F149 D363 A365 R367 N368 D381 P402 D130 A132 R134 N135 D148 P168 2.7.10.2 0004672,0004713,0005524,0006468 IC50=10.8nM P00520 20450175 1 MDPSYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 3mss C 1.95 BS02 MS7 C 1 L341 A433 P465 V468 L108 A199 P231 V234 D363 A365 R367 N368 D381 P402 D130 A132 R134 N135 D148 P168 2.7.10.2 0004672,0004713,0005524,0006468 P00520 20450175 516 MDPSYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 3mss D 1.95 BS01 STI D 1 L248 Y253 A269 K271 E286 M290 I313 T315 F317 M318 I360 H361 L370 A380 D381 F382 L21 Y26 A42 K44 E53 M57 I80 T82 F84 M85 I127 H128 L137 A147 D148 F149 D363 A365 R367 N368 D381 P402 D130 A132 R134 N135 D148 P168 2.7.10.2 0004672,0004713,0005524,0006468 IC50=10.8nM P00520 20450175 1 MDPSYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 3mss D 1.95 BS02 MS7 D 1 L341 A433 P465 V468 L108 A199 P231 V234 D363 A365 R367 N368 D381 P402 D130 A132 R134 N135 D148 P168 2.7.10.2 0004672,0004713,0005524,0006468 P00520 20450175 516 MDPSYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ