3pyy A 1.85 BS01 STI A 1 L267 Y272 A288 K290 E305 M309 V318 T334 F336 M337 I379 H380 A399 D400 F401 L17 Y22 A38 K40 E51 M55 V64 T80 F82 M83 I125 H126 A145 D146 F147 D382 A384 R386 N387 D400 P421 D128 A130 R132 N133 D146 P167 2.7.10.2 0004672,0004713,0005524,0006468 IC50=38nM, Kd=44nM, Ki=13nM, EC50=7e+1nM P00519 21338916 3 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES 3pyy A 1.85 BS02 3YY A 1 A356 L359 L360 L448 I451 A452 G482 C483 P484 A102 L105 L106 L194 I197 A198 G228 C229 P230 D382 A384 R386 N387 D400 P421 D128 A130 R132 N133 D146 P167 2.7.10.2 0004672,0004713,0005524,0006468 -logKd/Ki=6.86, Kd=137nM IC50=398nM, EC50=794nM P00519 21338916 538 YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQES 3pyy B 1.85 BS01 STI B 1 Y272 V275 K290 E305 M309 I332 T334 F336 M337 I379 H380 L389 A399 D400 F401 Y21 V24 K39 E48 M52 I75 T77 F79 M80 I122 H123 L132 A142 D143 F144 D382 A384 R386 N387 D400 P421 D125 A127 R129 N130 D143 P149 2.7.10.2 0004672,0004713,0005524,0006468 IC50=38nM, Kd=44nM, Ki=13nM, EC50=7e+1nM P00519 21338916 4 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKEL 3pyy B 1.85 BS02 3YY B 1 A356 L359 L448 I451 A452 G482 C483 P484 A99 L102 L176 I179 A180 G210 C211 P212 D382 A384 R386 N387 D400 P421 D125 A127 R129 N130 D143 P149 2.7.10.2 0004672,0004713,0005524,0006468 IC50=398nM, EC50=794nM P00519 21338916 532 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKEL