4nkv A 2.646 BS01 HEM A 1 R96 I112 A113 R125 A302 T306 V366 I371 H373 P434 F435 R440 C442 I443 G444 R66 I82 A83 R95 A265 T269 V329 I334 H336 P397 F398 R403 C405 I406 G407 T306 F435 C442 T269 F398 C405 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006629,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016491,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0043231,0046872,0047442 P05093 25301938 600 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkv A 2.646 BS02 AER A 1 L105 A113 N202 D298 G301 A302 T306 V366 L75 A83 N172 D261 G264 A265 T269 V329 T306 F435 C442 T269 F398 C405 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006629,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016491,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0043231,0046872,0047442 IC50=72nM P05093 25301938 601 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkv B 2.646 BS01 HEM B 1 R96 I112 A113 R125 A302 G303 T306 V366 L370 I371 H373 P434 F435 R440 C442 I443 R67 I83 A84 R96 A266 G267 T270 V330 L334 I335 H337 P398 F399 R404 C406 I407 T306 F435 C442 T270 F399 C406 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006629,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016491,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0043231,0046872,0047442 P05093 25301938 600 SLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkv B 2.646 BS02 AER B 1 Y201 N202 T306 Y172 N173 T270 T306 F435 C442 T270 F399 C406 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006629,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016491,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0043231,0046872,0047442 IC50=72nM P05093 25301938 601 SLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkv C 2.646 BS01 HEM C 1 R96 I112 A113 R125 A302 G303 T306 V366 I371 H373 P434 F435 R440 C442 I443 G444 R66 I82 A83 R95 A270 G271 T274 V334 I339 H341 P402 F403 R408 C410 I411 G412 T306 F435 C442 T274 F403 C410 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006629,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016491,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0043231,0046872,0047442 P05093 25301938 600 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkv C 2.646 BS02 AER C 1 A113 N202 D298 T306 A83 N172 D266 T274 T306 F435 C442 T274 F403 C410 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006629,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016491,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0043231,0046872,0047442 IC50=72nM P05093 25301938 601 LLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkv D 2.646 BS01 HEM D 1 R96 I112 A113 W121 R125 A302 G303 T306 V366 I371 H373 P434 F435 R440 C442 I443 R67 I83 A84 W92 R96 A265 G266 T269 V329 I334 H336 P397 F398 R403 C405 I406 T306 F435 C442 T269 F398 C405 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006629,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016491,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0043231,0046872,0047442 P05093 25301938 600 SLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ 4nkv D 2.646 BS02 AER D 1 L105 A113 F114 Y201 N202 I205 G297 D298 G301 A302 L76 A84 F85 Y172 N173 I176 G260 D261 G264 A265 T306 F435 C442 T269 F398 C405 1.14.14.19,1.14.14.32 0004497,0004508,0005506,0005783,0005789,0006629,0006694,0006702,0006704,0007548,0008202,0008395,0016020,0016491,0016705,0016829,0019825,0020037,0030424,0042445,0042446,0042448,0043025,0043231,0046872,0047442 IC50=72nM P05093 25301938 601 SLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDILSNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQ