4zhx A 2.99 BS01 4O7 A 1 L22 G23 G25 V30 A43 K45 E94 Y95 V96 E100 E143 N144 L146 D157 L14 G15 G17 V22 A35 K37 E86 Y87 V88 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.31 0000166,0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006629,0006631,0006633,0006694,0006695,0006914,0007165,0008202,0008203,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016126,0016239,0016241,0016301,0016310,0016607,0016740,0030424,0030425,0031331,0031588,0031669,0032007,0034599,0035556,0042149,0042593,0042752,0043025,0043066,0045821,0046872,0047322,0048511,0050405,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 26952388 601 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDANVIDDEAVKEVCEAVAYHLIIDNRRIMNQASEFYLASKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDLGSHTMDFFEMCASLITTL 4zhx A 2.99 BS02 C1V B 1 G19 K29 K31 I46 D88 G11 K21 K23 I38 D80 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.31 0000166,0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006629,0006631,0006633,0006694,0006695,0006914,0007165,0008202,0008203,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016126,0016239,0016241,0016301,0016310,0016607,0016740,0030424,0030425,0031331,0031588,0031669,0032007,0034599,0035556,0042149,0042593,0042752,0043025,0043066,0045821,0046872,0047322,0048511,0050405,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 26952388 301 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDANVIDDEAVKEVCEAVAYHLIIDNRRIMNQASEFYLASKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDLGSHTMDFFEMCASLITTL 4zhx B 2.99 BS01 C1V B 1 R83 T106 R107 S108 V113 R6 T29 R30 S31 V36 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006629,0006631,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 Kd=487nM, EC50=390nM Q9Y478 26952388 301 RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKQEPYVCKFRAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKP 4zhx C 2.99 BS01 4O7 C 1 L22 G23 G25 V30 A43 E94 Y95 V96 E100 E143 N144 L146 D157 L14 G15 G17 V22 A35 E86 Y87 V88 E92 E135 N136 L138 D149 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.31 0000166,0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006629,0006631,0006633,0006694,0006695,0006914,0007165,0008202,0008203,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016126,0016239,0016241,0016301,0016310,0016607,0016740,0030424,0030425,0031331,0031588,0031669,0032007,0034599,0035556,0042149,0042593,0042752,0043025,0043066,0045821,0046872,0047322,0048511,0050405,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 26952388 601 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDANVIDDEAVKEVCECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSSAMHIPPGLKPHPERMPPLIAAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4zhx C 2.99 BS02 C1V C 1 V11 G19 K29 K31 I46 D88 V3 G11 K21 K23 I38 D80 D139 K141 E143 N144 D157 S176 D131 K133 E135 N136 D149 S168 2.7.11.1,2.7.11.31 0000166,0003682,0004672,0004674,0004679,0004712,0005515,0005524,0005634,0005654,0005737,0005794,0005829,0006325,0006338,0006468,0006629,0006631,0006633,0006694,0006695,0006914,0007165,0008202,0008203,0008610,0010468,0010494,0010508,0010629,0014850,0016055,0016126,0016239,0016241,0016301,0016310,0016607,0016740,0030424,0030425,0031331,0031588,0031669,0032007,0034599,0035556,0042149,0042593,0042752,0043025,0043066,0045821,0046872,0047322,0048511,0050405,0055089,0062028,0070507,0071277,0071333,0071380,0071466,0097009,0106310,0140823,1903829,1903944,1904262,1904428,1905691,1990044,2000758 P54646 26952388 602 GRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQGLPSYLFPEDPSYDANVIDDEAVKEVCECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSSAMHIPPGLKPHPERMPPLIAAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDLGSHTMDFFEMCASLITTLA 4zhx D 2.99 BS01 C1V C 1 V81 R83 S108 V113 V4 R6 S31 V36 ? 0004672,0005515,0005634,0005654,0005737,0005829,0006468,0006629,0006631,0006633,0007165,0010628,0019901,0031588,0031669,0032991,0035878,0120162 Kd=487nM, EC50=390nM Q9Y478 26952388 602 RPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSHNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDEPYVCKPERAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKP 4zhx E 2.99 BS01 C2Z E 1 H151 R152 S226 H298 R299 S314 S316 H125 R126 S200 H272 R273 S288 S290 ? 0000166,0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006629,0006631,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 26952388 401 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVL 4zhx E 2.99 BS02 C2Z E 2 T87 T89 H151 S242 K243 F244 T61 T63 H125 S216 K217 F218 ? 0000166,0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006629,0006631,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 26952388 402 SVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVL 4zhx F 2.99 BS01 AMP F 1 R70 K170 I240 S242 F244 D245 R269 F273 L277 V297 R299 R45 K145 I215 S217 F219 D220 R244 F248 L252 V272 R274 ? 0000166,0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006629,0006631,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 26952388 401 NSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLT 4zhx F 2.99 BS02 AMP F 2 H151 T200 I204 A205 V225 S226 I312 S314 S316 D317 H126 T175 I179 A180 V200 S201 I287 S289 S291 D292 ? 0000166,0004672,0004691,0005515,0005524,0005634,0005654,0005737,0005829,0006110,0006468,0006629,0006631,0006633,0007165,0007283,0008603,0010628,0016020,0016208,0019887,0019901,0031588,0031669,0043531,0045860,0051170 P54619 26952388 402 NSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLT