5ftj A 2.3 BS01 ADP A 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 807 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj A 2.3 BS02 ADP A 2 D478 I479 G480 G521 C522 G523 K524 T525 L526 I656 G684 A685 T688 D458 I459 G460 G501 C502 G503 K504 T505 L506 I636 G664 A665 T668 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 900 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj A 2.3 BS03 OJA A 1 V493 P496 S511 C535 A537 P571 K614 N616 V617 F618 V473 P476 S491 C515 A517 P551 K594 N596 V597 F598 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=20nM P55072 26822609 1001 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj B 2.3 BS01 ADP B 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 807 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj B 2.3 BS02 ADP B 2 D478 I479 G480 G521 C522 G523 K524 T525 L526 I656 G684 A685 T688 D458 I459 G460 G501 C502 G503 K504 T505 L506 I636 G664 A665 T668 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 900 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj B 2.3 BS03 OJA B 1 V493 P496 S511 C535 A537 P571 K614 N616 V617 F618 V473 P476 S491 C515 A517 P551 K594 N596 V597 F598 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=20nM P55072 26822609 1001 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj C 2.3 BS01 ADP C 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 807 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj C 2.3 BS02 ADP C 2 D478 I479 G480 G521 C522 G523 K524 T525 L526 I656 G684 A685 T688 D458 I459 G460 G501 C502 G503 K504 T505 L506 I636 G664 A665 T668 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 900 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj C 2.3 BS03 OJA C 1 V493 P496 S511 C535 A537 P571 K614 N616 V617 F618 V473 P476 S491 C515 A517 P551 K594 N596 V597 F598 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=20nM P55072 26822609 1001 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj D 2.3 BS01 ADP D 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 807 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj D 2.3 BS02 ADP D 2 D478 I479 G480 G521 C522 G523 K524 T525 L526 I656 G684 A685 T688 D458 I459 G460 G501 C502 G503 K504 T505 L506 I636 G664 A665 T668 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 900 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj D 2.3 BS03 OJA D 1 V493 P496 S511 C535 A537 P571 K614 N616 V617 F618 V473 P476 S491 C515 A517 P551 K594 N596 V597 F598 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=20nM P55072 26822609 1001 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj E 2.3 BS01 ADP E 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 807 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj E 2.3 BS02 ADP E 2 D478 I479 G480 G521 C522 G523 K524 T525 L526 I656 G684 A685 T688 D458 I459 G460 G501 C502 G503 K504 T505 L506 I636 G664 A665 T668 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 900 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj E 2.3 BS03 OJA E 1 V493 P496 S511 C535 A537 P571 K614 N616 V617 F618 V473 P476 S491 C515 A517 P551 K594 N596 V597 F598 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=20nM P55072 26822609 1001 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj F 2.3 BS01 ADP F 1 G207 G248 T249 G250 K251 T252 L253 I380 H384 G408 A409 G187 G228 T229 G230 K231 T232 L233 I360 H364 G388 A389 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 807 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj F 2.3 BS02 ADP F 2 D478 I479 G480 G521 C522 G523 K524 T525 L526 I656 G684 A685 T688 D458 I459 G460 G501 C502 G503 K504 T505 L506 I636 G664 A665 T668 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 P55072 26822609 900 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ 5ftj F 2.3 BS03 OJA F 1 V493 P496 S511 C535 A537 P571 K614 N616 V617 F618 V473 P476 S491 C515 A517 P551 K594 N596 V597 F598 K251 T252 D304 N348 R453 K524 T525 D577 E578 D609 A685 K231 T232 D284 N328 R433 K504 T505 D557 E558 D589 A665 3.6.4.6 0000166,0000502,0003723,0005515,0005524,0005576,0005634,0005654,0005737,0005783,0005789,0005811,0005829,0006281,0006302,0006511,0006734,0006888,0006914,0006919,0006974,0008289,0010494,0010498,0010918,0016236,0016567,0016787,0016887,0019079,0019903,0019904,0019985,0030968,0030970,0031334,0031593,0031625,0032436,0032510,0032991,0033554,0034098,0034605,0034774,0035578,0035617,0035800,0035861,0036297,0036435,0036503,0036513,0042288,0042802,0042981,0043161,0043231,0043531,0044389,0044877,0045184,0045202,0045732,0045879,0046034,0048471,0050807,0051228,0061857,0070062,0070842,0071218,0072389,0090263,0097352,0098978,0106300,0120186,0140036,1901224,1903006,1903007,1903715,1903843,1903862,1904288,1904813,1904949,1905634,1990381,1990730,2000060,2001171 IC50=20nM P55072 26822609 1001 NRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLKGKKRREAVCIVLSDDTCSDEKIRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGCRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVINQILTEMDGMSTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRVAILKANLRKSPVAKDVDLEFLAKMTNGFSGADLTEICQRACKLAIRESIESEIVPEIRRDHFEEAMRFARRSVSDNDIRKYEMFAQTLQ