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I-TASSER QUARK LOMETS COACH COFACTOR MUSTER SEGMER FG-MD ModRefiner REMO SPRING COTH BSpred SVMSEQ ANGLOR BSP-SLIM SAXSTER ThreaDom EvoDesign GPCR-I-TASSER BindProf BindProfX ResQ IonCom STRUM

TM-score TM-align MMalign NWalign EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot I-TASSER-MR

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP TM-fold DECOYS POTENTIAL RW HPSF CASP7 CASP8 CASP9 CASP10 CASP11 CASP12




COACH is a meta-server approach to protein-ligand binding site prediction. Starting from given structure of target proteins, COACH will generate complementray ligand binding site predictions using two comparative methods, TM-SITE and S-SITE, which recognize ligand-binding templates from the BioLiP protein function database by binding-specific substructure and sequence profile comparisons. These predictions will be combined with results from other methods (including COFACTOR, FINDSITE and ConCavity to generate final ligand binding site predictions. Users are also allowed to input primary sequence, where I-TASSER will be used to generate 3D models first which are then fed into the COACH pipeline for ligand-binding site prediction. The COACH algorithm was ranked as the best method in the weekly CAMEO ligand Binding Site Prediction Experiments.

Please post questions and suggestions about the COACH server at the Service System Discussion Board, whereby some members will response to your poster asap.

Download the standalone COACH Package through I-TASSER Suite

[Download] [Queue] [Library] [Example] [Forum]

Please copy and paste your data below (either structure in PDB format or sequence in FASTA format is acceptable)
Click for an example PDB input    Click for an example FASTA input

Or upload the stucture/sequence file:

Email: (Optional, where results will be sent to)

ID: (Optional, your given name to this protein)


References:

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