COACH is a meta-server approach to protein-ligand binding site prediction.
Starting from given structure of target proteins, COACH will generate
complementray ligand binding site predictions using two comparative methods, TM-SITE
and S-SITE, which recognize ligand-binding templates from the
BioLiP protein function database
by binding-specific substructure and sequence profile comparisons.
These predictions will be combined with results from other methods (including
to generate final ligand binding site predictions.
Users are also allowed to input primary sequence, where
will be used to generate 3D models first which are
then fed into the COACH pipeline for ligand-binding site prediction.
The COACH algorithm was ranked as the best method in the
weekly CAMEO ligand Binding Site Prediction Experiments
Please post questions and suggestions about the COACH server at the
whereby some members will response to your poster asap.
Download the standalone COACH Package through I-TASSER Suite