COFACTOR is a structure-based method for biological function annotation of protein molecules. To use COFACTOR, user needs to provide a 3D-structural model of the protein of interest. COFACTOR will thread the structure through three comprehensive function libraries by local and global structure matches to identify functional sites and homologies. Functional insights, including ligand-binding site, gene-ontology terms, and enzyme classification, will be derived from the best functional homology template. The COFACTOR algorithm was ranked as the best method for function prediction in the community-wide CASP9 experiments held in 2010.


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Copy and paste your structure file here (in PDB format)   Sample input

Or upload the stucture file (all atom or C-alpha only) from your local computer (PDB format):

Email: (Optional, where results will be sent to)

ID: (Optional, your given name to this protein)

References:
  • Ambrish Roy, Jianyi Yang, and Yang Zhang. COFACTOR: An accurate comparative algorithm for structure-based protein function annotation. Nucleic Acids Research, in press (2012).
  • Ambrish Roy, Yang Zhang. Recognizing protein-ligand binding sites by global structural alignment and local geometry refinement. Structure, in press (2012).

 


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