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COFACTOR is a structure-based method for biological function annotation of protein molecules. To use COFACTOR, user needs to provide a 3D-structural model of the protein of interest. COFACTOR will thread the structure through the BioLiP protein funtion database by local and global structure matches to identify functional sites and homologies. Functional insights, including ligand-binding site, gene-ontology terms, and enzyme classification, will be derived from the best functional homology template. The COFACTOR algorithm was ranked as the best method for function prediction in the community-wide CASP9 experiments held in 2010. Questions about the COFACTOR server can be posted at the Service System Discussion Board.

For a given target structure, the output of COFACTOR includes (see an illustrative example):

  • The top 10 closest structures in the PDB searched by TM-align
  • Enzyme classification of the target protein and the top 5 enzyme homologs in the PDB
  • Gene Ontology (GO) terms associated with the target protein
  • Possible binding ligands and the ligand-protein complex structures

[Forum] [Library] [Example predictions] [Help]
Copy and paste your structure file here (in PDB format)   Sample input

Or upload the stucture file (all atom or C-alpha only) from your local computer (PDB format):

Email: (Mandatory, where results will be sent to)

ID: (Optional, your given name to this protein)


References:

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