COTH (CO-THreader) is a multiple-chain protein threading algorithm to identify and recombine protein complex structures from both tertiary and complex structure libraries. It first generates complex query-template alignments by sequence profile-profile alignment assisted by the ab initio binding-site predictions from BSpred. The monomer structures from tertiary template library are then combined into the complex framework by structure superposition (More about the server ...).

The output of the COTH server include (An example of the COTH output):

  • Top ten template proteins and the query-template alignments from COTH threading.
  • COTH recombination models generated by superposition of MUSTER individual chain template on the multimeric template framework of COTH threading.

Cut and paste your first sequence in FASTA format here:

Or upload the sequence from your local computer:

Cut and paste your second sequence in FASTA format here:

Or upload the sequence from your local computer:

Email: (mandatory, where results will be sent to)

ID: (optional, your given name of the protein)



Reference:
S. Mukherjee, Y. Zhang. Protein-protein complex structure prediction by multimeric threading and template recombination. Submitted (2010). 		 


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