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Name | Mu-type opioid receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | OPRM1 |
Synonym | hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor [ Show all ] |
Disease | Diarrhea Inflammatory disease Pain Major depressive disorder Migraine [ Show all ] |
Length | 400 |
Amino acid sequence | MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP |
UniProt | P35372 |
Protein Data Bank | N/A |
GPCR-HGmod model | P35372 |
3D structure model | This predicted structure model is from GPCR-EXP P35372. |
BioLiP | N/A |
Therapeutic Target Database | T47768 |
ChEMBL | CHEMBL233 |
IUPHAR | 319 |
DrugBank | BE0000770 |
Name | Norbinaltorphimine |
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Molecular formula | C40H43N3O6 |
IUPAC name | (1S,2S,7S,8S,12R,20R,24R,32R)-11,33-bis(cyclopropylmethyl)-19,25-dioxa-11,22,33-triazaundecacyclo[24.9.1.18,14.01,24.02,32.04,23.05,21.07,12.08,20.030,36.018,37]heptatriaconta-4(23),5(21),14(37),15,17,26,28,30(36)-octaene-2,7,17,27-tetrol |
Molecular weight | 661.799 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 5 |
XlogP | 3.2 |
Synonyms | CHEMBL573214 NCGC00024547-04 PDSP2_001420 4,8:11,15-Dimethano-20H-bisbenzofuro(2,3-a:3',2'-i)dipyrido(4,3-b:3',4'-h)carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-, (4bS,8R,8aS,10aS,11R,14aS,19aR,20bR)- C18130 [ Show all ] |
Inchi Key | APSUXPSYBJVPPS-YAUKWVCOSA-N |
Inchi ID | InChI=1S/C40H43N3O6/c44-25-7-5-21-13-27-39(46)15-23-24-16-40(47)28-14-22-6-8-26(45)34-30(22)38(40,10-12-43(28)18-20-3-4-20)36(49-34)32(24)41-31(23)35-37(39,29(21)33(25)48-35)9-11-42(27)17-19-1-2-19/h5-8,19-20,27-28,35-36,41,44-47H,1-4,9-18H2/t27-,28-,35+,36+,37+,38+,39-,40-/m1/s1 |
PubChem CID | 5480230 |
ChEMBL | CHEMBL573214 |
IUPHAR | 1642 |
BindingDB | 82551 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 200.0 % | PMID20568781 | ChEMBL |
EC50 | 18.9 Ke nM-1 | PMID12672258 | ChEMBL |
EC50 | 19.0 nM | PMID12672258 | BindingDB |
EC50 | 120.0 nM | PMID20568781 | BindingDB,ChEMBL |
IC50 | 212.0 nM | PMID20727752, PMID20719509 | BindingDB,ChEMBL |
Kb | 32.9 nM | PMID21958337 | ChEMBL |
Ke | 17.0 nM | PMID21570305 | ChEMBL |
Ke | 18.9 nM | PMID15456250, PMID12519069, PMID24973818, PMID14640558 | ChEMBL |
Ke | 19.0 nM | PMID12825951, PMID12723940, PMID16366600, PMID12139463 | ChEMBL |
Ke | 26.0 nM | PMID26342544, PMID16509593, PMID17685652, PMID19954245 | ChEMBL |
Ke | 26.7 nM | PMID23651437, PMID20568781 | ChEMBL |
Ki | 0.94 nM | PMID10780914 | ChEMBL |
Ki | 0.94 nM | PMID10780914 | BindingDB |
Ki | 2.2 nM | PMID8114680 | BindingDB |
Ki | 2.7 nM | PMID19027293 | BindingDB,ChEMBL |
Ki | 18.9 nM | PMID11055333 | ChEMBL |
Ki | 19.0 nM | PMID11055333 | BindingDB |
Ki | 19.9526 nM | PMID9686407 | IUPHAR |
Ki | 21.0 nM | PMID12672258, PMID9686407, PMID14640558, PMID12519069, PMID24973818, PMID11055333, PMID15456250, PMID12825951 | BindingDB,ChEMBL |
Ki | 32.0 nM | PMID21958337 | BindingDB |
Ki | 32.4 nM | PMID21958337 | ChEMBL |
Ki | 56.0 nM | PMID10893307 | BindingDB,ChEMBL |
Ki | 70.0 nM | PMID10780914 | BindingDB,ChEMBL |
Ki | 79.0 nM | PMID12747782 | BindingDB |
Ki | 79.4 nM | PMID12747782 | ChEMBL |
Ki | 79.9 nM | PMID21744827 | ChEMBL |
Ki | 80.0 nM | PMID21744827 | BindingDB |
Ratio | 1.5 - | PMID12565965 | ChEMBL |
Ratio | 5.6 - | PMID1849995 | ChEMBL |
Ratio | 8.3 - | PMID1849995 | ChEMBL |
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