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Name | Alpha-2A adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRA2A |
Synonym | alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A [ Show all ] |
Disease | Attention deficit hyperactivity disorder Sexual dysfunction Pain |
Length | 450 |
Amino acid sequence | MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV |
UniProt | P08913 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08913 |
3D structure model | This predicted structure model is from GPCR-EXP P08913. |
BioLiP | N/A |
Therapeutic Target Database | T11448 |
ChEMBL | CHEMBL1867 |
IUPHAR | 25 |
DrugBank | BE0000289 |
Name | Atipamezole |
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Molecular formula | C14H16N2 |
IUPAC name | 5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole |
Molecular weight | 212.296 |
Hydrogen bond acceptor | 1 |
Hydrogen bond donor | 1 |
XlogP | 3.0 |
Synonyms | AC-1614 Antisedan Atipamezole, >=98% (HPLC) CAS-104054-27-5 DSSTox_CID_29061 [ Show all ] |
Inchi Key | HSWPZIDYAHLZDD-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16) |
PubChem CID | 71310 |
ChEMBL | CHEMBL353972 |
IUPHAR | N/A |
BindingDB | 81807 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.33 nM | PMID1656026 | BindingDB |
Ki | 1.2 nM | PMID27265687 | BindingDB,ChEMBL |
Ki | 1.862 nM | PMID20809632 | ChEMBL |
Ki | 1.9 nM | PMID20809632 | BindingDB |
Ki | 3.162 nM | PMID11262089 | ChEMBL |
pKb | 8.05 - | PMID20809632 | ChEMBL |
pKB | 8.9 - | PMID11262089 | ChEMBL |
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