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GPCR

Name	Alpha-2C adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2C
Synonym	alpha2-C4 Adra-2c ADRA2L2 ADRA2RL2 Adrenergic alpha2C- receptor class I adrenergic receptor alpha-2 adrenergic receptor subtype C4 alpha2C-adrenoceptor alpha-2C adrenergic receptor Alpha-2C adrenoceptor alpha-2C adrenoreceptor Alpha-2CAR [ Show all ]
Disease	Diabetic nephropathy; Fibromyalgia Hypertension Heart failure Glaucoma Alzheimer disease Asthma Erythema Contusion Depression Hypotension Male sexual disorders Neurological disease Obesity Ocular disease Allergic rhinitis Alcohol use disorders Ocular hypertension Poison intoxication Peptic ulcer Pain [ Show all ]
Length	462
Amino acid sequence	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProt	P18825
Protein Data Bank	N/A
GPCR-HGmod model	P18825
3D structure model	This predicted structure model is from GPCR-EXP P18825.
BioLiP	N/A
Therapeutic Target Database	T01777
ChEMBL	CHEMBL1916
IUPHAR	27
DrugBank	BE0004864, BE0000342, BE0004888

Ligand

Name	Atipamezole
Molecular formula	C14H16N2
IUPAC name	5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole
Molecular weight	212.296
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	3.0
Synonyms	MPV1248 RL00197 Tox21_113005_1 4-(2-ethyl-2,3-dihydro-1h-inden-2-yl)-1h-imidazole AC-1614 Antisedan Atipamezole, >=98% (HPLC) CAS-104054-27-5 DSSTox_CID_29061 J-513300 NCGC00182707-03 SC-27035 054A275 Zeolite,type: ZSM-5 5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole ACMC-20bb9y Atipamezol [Spanish] Atipamezolum [Latin] CHEMBL353972 DTXSID2049135 LS-171901 PDSP2_001566 SR-01000944943-1 1H-Imidazole, 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)- AN-14783 Atipamezole [USAN:BAN:INN] BDBM81807 D03002 HY-12380A MPV 1248 NCGC00182707-01 s4650 UNII-03N9U5JAF6 4-(2-Ethyl-2-indanyl)imidazole AC1L2FXQ Antisedan (TN) Atipamezole; MPV-1248 CAS_104054-27-5 DSSTox_GSID_49135 KB-47451 NSC_71310 SCHEMBL304971 104054-27-5 ZINC5424171 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole AKOS015900246 BC226060 CS-3390 EBD30510 MFCD00864502 PubChem21912 Tox21_113005 308081-08-5 A26271 antipamezole Atipamezole [USAN:INN:BAN] C14H16N2 D05OVC I14-1027 MPV-1248 NCGC00182707-02 SC-21403 03N9U5JAF6 Zeolite, type: ZSM-5 4-(2-ethyl-2-indanyl)imidazole; 4-(2-ethyl-2,3-dihydro-1h-inden-2-yl)-1h-imidazole AC1Q4WOE Atipamezol Atipamezolum DSSTox_RID_83274 L000823 PDSP1_001582 SR-01000944943 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)- 5-(2-ethylindan-2-yl)-1H-imidazole AKOS032960366 Atipamezole (USAN/INN) BCP02215 CTK4A2660 FT-0603697 MolPort-042-652-814 [ Show all ]
Inchi Key	HSWPZIDYAHLZDD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16)
PubChem CID	71310
ChEMBL	CHEMBL353972
IUPHAR	N/A
BindingDB	81807
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4.169 nM	PMID20809632	ChEMBL
Ki	4.2 nM	PMID20809632	BindingDB

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