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Name | Motilin receptor |
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Species | Homo sapiens (Human) |
Gene | MLNR |
Synonym | GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR [ Show all ] |
Disease | Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder [ Show all ] |
Length | 412 |
Amino acid sequence | MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG |
UniProt | O43193 |
Protein Data Bank | N/A |
GPCR-HGmod model | O43193 |
3D structure model | This predicted structure model is from GPCR-EXP O43193. |
BioLiP | N/A |
Therapeutic Target Database | T62306 |
ChEMBL | CHEMBL2203 |
IUPHAR | 297 |
DrugBank | BE0003521 |
Name | CHEMBL212044 |
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Molecular formula | C35H41Cl3N4O4 |
IUPAC name | N-benzyl-2,2,2-trichloro-N-[3-[[3-(2-morpholin-4-ylethoxy)-N-(phenylcarbamoyl)anilino]methyl]cyclohexyl]acetamide |
Molecular weight | 688.087 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 6.7 |
Synonyms | rac-1-((3-(N-benzyl-2,2,2-trichloroacetamido)cyclohexyl)methyl)-1-(3-(2-morpholinoethoxy)phenyl)-3-phenylurea BDBM50186115 |
Inchi Key | IFLWLFWRVQTDET-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C35H41Cl3N4O4/c36-35(37,38)33(43)41(25-27-9-3-1-4-10-27)30-14-7-11-28(23-30)26-42(34(44)39-29-12-5-2-6-13-29)31-15-8-16-32(24-31)46-22-19-40-17-20-45-21-18-40/h1-6,8-10,12-13,15-16,24,28,30H,7,11,14,17-23,25-26H2,(H,39,44) |
PubChem CID | 44412977 |
ChEMBL | N/A |
IUPHAR | N/A |
BindingDB | 50186115 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 957.0 nM | PMID16650762 | BindingDB |
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