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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | CHEMBL2207638 |
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Molecular formula | C28H35N3O |
IUPAC name | 1-(2-methoxyphenyl)-4-[[3-(piperidin-1-ylmethyl)azulen-1-yl]methyl]piperazine |
Molecular weight | 429.608 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 5.0 |
Synonyms | BDBM50401947 |
Inchi Key | IOFOPIMDJBEBFZ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H35N3O/c1-32-28-13-7-6-12-27(28)31-18-16-30(17-19-31)22-24-20-23(21-29-14-8-3-9-15-29)25-10-4-2-5-11-26(24)25/h2,4-7,10-13,20H,3,8-9,14-19,21-22H2,1H3 |
PubChem CID | 71457844 |
ChEMBL | CHEMBL2207638 |
IUPHAR | N/A |
BindingDB | 50401947 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 37.0 nM | PMID23099096 | BindingDB,ChEMBL |
Ki | 51.0 nM | PMID23099096 | BindingDB,ChEMBL |
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