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Name | Nociceptin receptor |
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Species | Homo sapiens (Human) |
Gene | OPRL1 |
Synonym | Orphanin FQ receptor OP4 NOPr NOP-r NOP receptor [ Show all ] |
Disease | Inflammatory disease Major depressive disorder Central nervous system disease Heart failure Anxiety disorder [ Show all ] |
Length | 370 |
Amino acid sequence | MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA |
UniProt | P41146 |
Protein Data Bank | 5dhh, 5dhg, 4ea3 |
GPCR-HGmod model | P41146 |
3D structure model | This structure is from PDB ID 5dhh. |
BioLiP | BL0328039,BL0328040, BL0328041,BL0328042, BL0227293,BL0227294 |
Therapeutic Target Database | T52921 |
ChEMBL | CHEMBL2014 |
IUPHAR | 320 |
DrugBank | BE0002378 |
Name | CHEMBL419272 |
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Molecular formula | C25H24BrN3O |
IUPAC name | 1-(3-bromophenyl)-8-(1,2-dihydroacenaphthylen-1-yl)-1,3,8-triazaspiro[4.5]decan-4-one |
Molecular weight | 462.391 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 5.1 |
Synonyms | 1-(3-Bromophenyl)-8-(acenaphthen-1-yl)-1,3,8-triazaspiro[4.5]decan-4-one |
Inchi Key | AVSGXJXRFGUGTJ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C25H24BrN3O/c26-19-7-3-8-20(15-19)29-16-27-24(30)25(29)10-12-28(13-11-25)22-14-18-6-1-4-17-5-2-9-21(22)23(17)18/h1-9,15,22H,10-14,16H2,(H,27,30) |
PubChem CID | 15512238 |
ChEMBL | CHEMBL419272 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 3.981 nM | PMID10476866 | ChEMBL |
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