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Name | Histamine H1 receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | HRH1 |
Synonym | HH1R H1R Hisr H1 receptor |
Disease | Vertigo's disease; Meniere's disease Ocular allergy Obesity Nausea; Vomiting Insomnia; Anxiety disorder [ Show all ] |
Length | 487 |
Amino acid sequence | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS |
UniProt | P35367 |
Protein Data Bank | 3rze |
GPCR-HGmod model | P35367 |
3D structure model | This structure is from PDB ID 3rze. |
BioLiP | BL0202178, BL0202179, BL0202180 |
Therapeutic Target Database | T77913 |
ChEMBL | CHEMBL231 |
IUPHAR | 262 |
DrugBank | BE0000442 |
Name | CHEMBL603049 |
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Molecular formula | C21H23FN2 |
IUPAC name | 8-fluoro-2-methyl-5-[2-(4-methylphenyl)ethyl]-3,4-dihydro-1H-pyrido[4,3-b]indole |
Molecular weight | 322.427 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 0 |
XlogP | 4.3 |
Synonyms | AKOS021644596 8-Fluoro-2-methyl-5-(2-p-tolylethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole ZINC45387342 BDBM50305268 MolPort-021-806-385 [ Show all ] |
Inchi Key | AVZFSLTZULXZCC-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H23FN2/c1-15-3-5-16(6-4-15)9-12-24-20-8-7-17(22)13-18(20)19-14-23(2)11-10-21(19)24/h3-8,13H,9-12,14H2,1-2H3 |
PubChem CID | 44126328 |
ChEMBL | CHEMBL603049 |
IUPHAR | N/A |
BindingDB | 50305268 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 31.0 nM | PMID19945877 | BindingDB,ChEMBL |
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