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Name | Glucagon-like peptide 1 receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Glp1r |
Synonym | GLP-1 receptor GLP-1-R GLP-1R glucagon-like peptide 1 receptor |
Disease | N/A for non-human GPCRs |
Length | 463 |
Amino acid sequence | MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS |
UniProt | P32301 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5862 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL449327 |
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Molecular formula | C54H52N4O16S2 |
IUPAC name | 2,4-bis[3-methoxy-4-(thiophene-2-carbonyloxy)phenyl]-1,3-bis[[4-[(2-methylpropan-2-yl)oxycarbonylamino]benzoyl]amino]cyclobutane-1,3-dicarboxylic acid |
Molecular weight | 1077.14 |
Hydrogen bond acceptor | 18 |
Hydrogen bond donor | 6 |
XlogP | 8.3 |
Synonyms | CHEMBL2158412 1,3-bis(4-(tert-butoxycarbonyl)benzamido)-2,4-bis(3-methoxy-4-(thiophene-2-carbonyloxy)phenyl)cyclobutane-1,3-dicarboxylic acid BDBM50260246 CHEMBL2158413 1,3-Bis[4-(tert-butyloxycarbonylamino)benzoylamino]-2,4-bis[3-methoxy-4-[(2-thienyl)carbonyloxy]phenyl]cyclobutane-1,3-dicarboxylic acid [ Show all ] |
Inchi Key | JSLFGFBQFKCNSQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C54H52N4O16S2/c1-51(2,3)73-49(67)55-33-19-13-29(14-20-33)43(59)57-53(47(63)64)41(31-17-23-35(37(27-31)69-7)71-45(61)39-11-9-25-75-39)54(48(65)66,58-44(60)30-15-21-34(22-16-30)56-50(68)74-52(4,5)6)42(53)32-18-24-36(38(28-32)70-8)72-46(62)40-12-10-26-76-40/h9-28,41-42H,1-8H3,(H,55,67)(H,56,68)(H,57,59)(H,58,60)(H,63,64)(H,65,66) |
PubChem CID | 16186241 |
ChEMBL | CHEMBL449327 |
IUPHAR | N/A |
BindingDB | 50260246 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <20000.0 nM | PMID22103243 | BindingDB |
EC50 | 370.7 nM | PMID22103243 | BindingDB |
EC50 | 846.8 nM | PMID22103243 | BindingDB |
EC50 | 2730.0 nM | PMID17213311 | BindingDB,ChEMBL |
IC50 | 600.0 nM | PMID22103243 | BindingDB |
IC50 | 1300.0 nM | PMID22103243 | BindingDB |
IC50 | 1600.0 nM | PMID22103243 | BindingDB |
IC50 | 3600.0 nM | PMID22103243 | BindingDB |
IC50 | 4300.0 nM | PMID22103243 | BindingDB |
Ki | 1470.0 nM | PMID17213311 | BindingDB,ChEMBL |
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