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Name | Histamine H4 receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | HRH4 |
Synonym | Pfi-013 SP9144 HH4R H4R H4 receptor [ Show all ] |
Disease | Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis |
Length | 390 |
Amino acid sequence | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS |
UniProt | Q9H3N8 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9H3N8 |
3D structure model | This predicted structure model is from GPCR-EXP Q9H3N8. |
BioLiP | N/A |
Therapeutic Target Database | T26500 |
ChEMBL | CHEMBL3759 |
IUPHAR | 265 |
DrugBank | BE0000146 |
Name | ISOLOXAPINE |
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Molecular formula | C18H18ClN3O |
IUPAC name | 3-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine |
Molecular weight | 327.812 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 3.1 |
Synonyms | 8-Chloro-11-(4-methyl-piperazin-1-yl)dibenzo[b,f][1,4]oxazepine LS-61561 BDBM50028980 D0Q2GP 8-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f][1,4]oxazepine [ Show all ] |
Inchi Key | AWHNHDGHHNGACT-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-16(14)23-17-7-6-13(19)12-15(17)20-18/h2-7,12H,8-11H2,1H3 |
PubChem CID | 10381810 |
ChEMBL | CHEMBL7828 |
IUPHAR | N/A |
BindingDB | 50028980 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 1.0 - | PMID16854056 | ChEMBL |
EC50 | 28.18 nM | PMID16854056 | ChEMBL |
Ki | 42.66 nM | PMID16854056 | ChEMBL |
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