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Name | 5-hydroxytryptamine receptor 6 |
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Species | Rattus norvegicus (Rat) |
Gene | Htr6 |
Synonym | 5-HT-6 5-HT6 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Serotonin receptor 6 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 436 |
Amino acid sequence | MVPEPGPVNSSTPAWGPGPPPAPGGSGWVAAALCVVIVLTAAANSLLIVLICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTAPRALALILGAWSLAALASFLPLLLGWHELGKARTPAPGQCRLLASLPFVLVASGVTFFLPSGAICFTYCRILLAARKQAVQVASLTTGTAGQALETLQVPRTPRPGMESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIAQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCVHCPPEHRPALPPPPCGPLTAVPDQASACSRCCLCLCRQTQIQTPLQGAPRACSSQPSFCCLERPPGTPRHPPGPPLWSTSLSQTLWSLRYGRIHSVPP |
UniProt | P31388 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3372 |
IUPHAR | 11 |
DrugBank | N/A |
Name | ritanserin |
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Molecular formula | C27H25F2N3OS |
IUPAC name | 6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one |
Molecular weight | 477.574 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 5.2 |
Synonyms | 6-(2-(4-(Bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl-5H-thiazolo((3,2-a)pyrimidin-5-one Lopac-R-103 6-(2-{4-[Bis-(4-fluoro-phenyl)-methylene]-piperidin-1-yl}-ethyl)-7-methyl-thiazolo[3,2-a]pyrimidin-5-one(Ritanserin) N,N-dialkyl-dipeptidylamines 6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidyl]ethyl]-7-methyl-thiazolo[3,2-a]pyrimidin-5-one [ Show all ] |
Inchi Key | JUQLTPCYUFPYKE-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3 |
PubChem CID | 5074 |
ChEMBL | CHEMBL267777 |
IUPHAR | 97 |
BindingDB | 50001775 |
DrugBank | DB12693 |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 15.84 nM | PMID7984267 | BindingDB |
Ki | 15.8489 - 316.228 nM | PMID7680751, PMID9225298, PMID9798944, PMID9730917 | IUPHAR |
Ki | 16.0 nM | PMID7680751 | BindingDB |
Ki | 33.88 nM | PMID9225298 | BindingDB |
Ki | 39.81 nM | PMID10821800 | BindingDB |
Ki | 43.65 nM | PMID7984267 | BindingDB |
Ki | 44.1 nM | PMID7680751 | BindingDB |
Ki | 316.22 nM | PMID9225298 | BindingDB |
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