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Name | B1 bradykinin receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Bdkrb1 |
Synonym | KB1 bradykinin receptor BKR1 BK-1 receptor B1R [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 337 |
Amino acid sequence | MASEVLLELQPSNRSLQAPANITSCESALEDWDLLYRVLPGFVITICFFGLLGNLLVLSFFLLPWRQWWWQQRQRQQRLTIAEIYLANLAASDLVFVLGLPFWAENIGNRFNWPFGTDLCRVVSGVIKANLFVSIFLVVAISQDRYRLLVYPMTSWGYRRRRQAQATCLLIWVAGGLLSIPTFLLRSVKVVPDLNVSACILLFPHEAWHFARMVELNVLGFLLPVTAIIFFNYHILASLRGQKEASRTRCGGPKGSKTTGLILTLVASFLVCWCPYHFFAFLDFLVQVRVIQDCSWKEITDLGLQLANFFAFVNSCLNPLIYVFAGRLLKTRVLGTL |
UniProt | P97583 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4613 |
IUPHAR | 41 |
DrugBank | N/A |
Name | CHEMBL134135 |
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Molecular formula | C40H64N12O8 |
IUPAC name | (2S,3aS,7aS)-1-[(3R)-2-[(2S)-2-[6-[[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanoylamino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid |
Molecular weight | 841.028 |
Hydrogen bond acceptor | 11 |
Hydrogen bond donor | 10 |
XlogP | -4.1 |
Synonyms | BDBM50408822 |
Inchi Key | KDYVEGLQNMHZED-FUPLYUBQSA-N |
Inchi ID | InChI=1S/C40H64N12O8/c41-27(13-8-18-47-39(42)43)34(55)50-28(14-9-19-48-40(44)45)35(56)46-17-7-1-2-16-33(54)49-29(23-53)36(57)51-22-26-12-4-3-10-24(26)20-31(51)37(58)52-30-15-6-5-11-25(30)21-32(52)38(59)60/h3-4,10,12,25,27-32,53H,1-2,5-9,11,13-23,41H2,(H,46,56)(H,49,54)(H,50,55)(H,59,60)(H4,42,43,47)(H4,44,45,48)/t25-,27+,28-,29-,30-,31+,32-/m0/s1 |
PubChem CID | 44354162 |
ChEMBL | CHEMBL134135 |
IUPHAR | N/A |
BindingDB | 50408822 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 1995.26 nM | PMID9986712 | BindingDB,ChEMBL |
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