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Name | Metabotropic glutamate receptor 3 |
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Species | Rattus norvegicus (Rat) |
Gene | Grm3 |
Synonym | mGluR3 mGlu3 receptor GPRC1C glutamate receptor |
Disease | N/A for non-human GPCRs |
Length | 879 |
Amino acid sequence | MKMLTRLQILMLALFSKGFLLSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKEYLLKINFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIKWEDAWAIGPVTIACLGFLCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL |
UniProt | P31422 |
Protein Data Bank | 2e4u, 2e4v, 2e4w, 2e4x, 2e4y |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 2e4u. |
BioLiP | BL0086116,BL0086117, BL0086120,BL0086121, BL0086118,BL0086119, BL0086114,BL0086115, BL0086112,BL0086113 |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3067 |
IUPHAR | 291 |
DrugBank | N/A |
Name | MGS-0028 |
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Molecular formula | C8H8FNO5 |
IUPAC name | (1R,2S,5S,6S)-2-amino-6-fluoro-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid |
Molecular weight | 217.152 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 3 |
XlogP | -4.2 |
Synonyms | (+/-)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid BDBM50094843 MGS0028 (1R,2S,5S,6S)-2-amino-6-fluoro-4-oxobicyclo[3.1.0]hexane-2,6-dicarboxylic acid CHEMBL121053 [ Show all ] |
Inchi Key | KFAGJPNFERWZJA-JKBXLQNXSA-N |
Inchi ID | InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1 |
PubChem CID | 9837317 |
ChEMBL | CHEMBL121053 |
IUPHAR | 1395 |
BindingDB | 50094843 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <100000.0 nM | PMID11123999 | BindingDB,ChEMBL |
EC50 | 2.07 nM | PMID11123999 | BindingDB,ChEMBL |
Ki | 3.62 nM | PMID11123999 | BindingDB,ChEMBL |
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