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Name | Orexin receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | HCRTR2 |
Synonym | Ox-2-R OX2 receptor Ox2-R OX2R orexin receptor type 2 [ Show all ] |
Disease | Insomnia |
Length | 444 |
Amino acid sequence | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW |
UniProt | O43614 |
Protein Data Bank | 5ws3, 5wqc, 4s0v, 4rnb |
GPCR-HGmod model | O43614 |
3D structure model | This structure is from PDB ID 5ws3. |
BioLiP | BL0303710, BL0398950, BL0397818, BL0302679 |
Therapeutic Target Database | T69485 |
ChEMBL | CHEMBL4792 |
IUPHAR | 322 |
DrugBank | BE0005865 |
Name | Orexin receptor antagonist 35 |
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Molecular formula | C23H20FN5O2 |
IUPAC name | 2-[(3R,6R)-1-(5-fluoro-2-pyrimidin-2-ylbenzoyl)-6-methylpiperidin-3-yl]oxypyridine-4-carbonitrile |
Molecular weight | 417.444 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 3.1 |
Synonyms | SCHEMBL14877388 CHEMBL3642148 US20130102619, 35 BDBM97403 |
Inchi Key | KJTXWAGVJWMGLM-CRAIPNDOSA-N |
Inchi ID | InChI=1S/C23H20FN5O2/c1-15-3-5-18(31-21-11-16(13-25)7-10-26-21)14-29(15)23(30)20-12-17(24)4-6-19(20)22-27-8-2-9-28-22/h2,4,6-12,15,18H,3,5,14H2,1H3/t15-,18-/m1/s1 |
PubChem CID | 71526649 |
ChEMBL | CHEMBL3642148 |
IUPHAR | N/A |
BindingDB | 97403 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1.0 nM | None | ChEMBL |
Ki | 1.0 nM | N/A | BindingDB |
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