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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	103851-74-7
Molecular formula	C8H8N4
IUPAC name	5-pyridin-4-yl-1H-imidazol-2-amine
Molecular weight	160.18
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	0.3
Synonyms	5-(Pyridin-4-yl)-1H-imidazol-2-amine SCHEMBL2768364 AKOS023362375 CTK0G6761 1H-Imidazol-2-amine, 4-(4-pyridinyl)- ACMC-20m6nh DTXSID50546463 1H-Imidazol-2-amine, 5-(4-pyridinyl)- AKOS014774837 CHEMBL306902 [ Show all ]
Inchi Key	AYMDMLFHNZJJEF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H8N4/c9-8-11-5-7(12-8)6-1-3-10-4-2-6/h1-5H,(H3,9,11,12)
PubChem CID	13676540
ChEMBL	CHEMBL306902
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kb	23600.0 nM	PMID2878075	ChEMBL

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