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Name | 5-hydroxytryptamine receptor 1B |
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Species | Homo sapiens (Human) |
Gene | HTR1B |
Synonym | 5-HT1B receptor 5-HT-1B 5-HT-1D-beta 5-HT1B Serotonin 1D beta receptor [ Show all ] |
Disease | Chronic schizophrenics Major depressive disorder Migraine headaches Mood disorder Psychotic disorders [ Show all ] |
Length | 390 |
Amino acid sequence | MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS |
UniProt | P28222 |
Protein Data Bank | 4iar, 6g79, 5v54 |
GPCR-HGmod model | P28222 |
3D structure model | This structure is from PDB ID 4iar. |
BioLiP | BL0239857, BL0403524,BL0403525, BL0417722 |
Therapeutic Target Database | T07806 |
ChEMBL | CHEMBL1898 |
IUPHAR | 2 |
DrugBank | BE0000797 |
Name | Ziprasidone |
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Molecular formula | C21H21ClN4OS |
IUPAC name | 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one |
Molecular weight | 412.936 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 4.0 |
Synonyms | 4770-EP2308875A1 NCGC00263539-01 5-[2-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-ethyl]-6-chloro-1,3-dihydro-indol-2-one(Norastemizole) TL8000889 5-{2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-2,3-dihydro-1H-indol-2-one [ Show all ] |
Inchi Key | MVWVFYHBGMAFLY-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27) |
PubChem CID | 60854 |
ChEMBL | CHEMBL708 |
IUPHAR | 59 |
BindingDB | 50048803 |
DrugBank | DB00246 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
Ki | 0.99 nM | PMID8935801 | PDSP,BindingDB |
Ki | 4.0 nM | http://pdsp.med.unc.edu/pdsp.php | PDSP |
Ki | 5.01187 nM | PMID8935801 | IUPHAR |
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