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Name | Orexin receptor type 2 |
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Species | Rattus norvegicus (Rat) |
Gene | Hcrtr2 |
Synonym | hypocretin receptor 2 Hypocretin receptor type 2 hypocretin (orexin) receptor 2 orexin receptor type 2 Ox-2-R [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 460 |
Amino acid sequence | MSSTKLEDSLPRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMERSSMLPGLANKTTLFTVCDERWGGEVYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKQPQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHRRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVALTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV |
UniProt | P56719 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1275216 |
IUPHAR | 322 |
DrugBank | N/A |
Name | SCHEMBL1717503 |
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Molecular formula | C23H23FN4O2 |
IUPAC name | [(2R,5R)-5-[(5-fluoropyridin-2-yl)oxymethyl]-2-methylpiperidin-1-yl]-(2-pyrimidin-2-ylphenyl)methanone |
Molecular weight | 406.461 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 3.5 |
Synonyms | CHEMBL3655679 BDBM104706 US8569311, 1-28 |
Inchi Key | NHPFQONZHFJUNT-IAGOWNOFSA-N |
Inchi ID | InChI=1S/C23H23FN4O2/c1-16-7-8-17(15-30-21-10-9-18(24)13-27-21)14-28(16)23(29)20-6-3-2-5-19(20)22-25-11-4-12-26-22/h2-6,9-13,16-17H,7-8,14-15H2,1H3/t16-,17-/m1/s1 |
PubChem CID | 59396033 |
ChEMBL | CHEMBL3655679 |
IUPHAR | N/A |
BindingDB | 104706 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.67 nM | , None | BindingDB,ChEMBL |
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