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GPCR

NameHistamine H4 receptor
SpeciesMus musculus (Mouse)
GeneHrh4
SynonymGPCR105
H4 receptor
H4R
HH4R
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
UniProtQ91ZY2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5657
IUPHAR265
DrugBankN/A

Ligand

Namehistamine
Molecular formulaC5H9N3
IUPAC name2-(1H-imidazol-5-yl)ethanamine
Molecular weight111.148
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP-0.7
SynonymsErgotidine
2631-EP2316831A1
.beta.-Aminoethylglyoxaline
51-45-6
163355-EP2284166A1
[ Show all ]
Inchi KeyNTYJJOPFIAHURM-UHFFFAOYSA-N
Inchi IDInChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
PubChem CID774
ChEMBLCHEMBL90
IUPHAR1204, 1247
BindingDB7966, 50121205
DrugBankDB05381

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5094.0 nMPMID27007611BindingDB,ChEMBL
EC505011.87 nMPMID21044842ChEMBL
Intrinsic activity1.0 -PMID21044842ChEMBL
Kd39.8107 nMPMID11561071IUPHAR
Ki39.8107 nMPMID11561071IUPHAR
Ki42.0 nMPMID25993395BindingDB,ChEMBL
Ki79.43 nMPMID21044842ChEMBL

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