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Name | Neuromedin-K receptor |
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Species | Homo sapiens (Human) |
Gene | TACR3 |
Synonym | SP-N receptor Tac3r Nmkr NKR NK3 receptor [ Show all ] |
Disease | Schizophrenia Schizophrenia; Schizoaffective disorders Psychotic disorders Psychiatric disorder Irritable bowel syndrome [ Show all ] |
Length | 465 |
Amino acid sequence | MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS |
UniProt | P29371 |
Protein Data Bank | N/A |
GPCR-HGmod model | P29371 |
3D structure model | This predicted structure model is from GPCR-EXP P29371. |
BioLiP | N/A |
Therapeutic Target Database | T29683 |
ChEMBL | CHEMBL4429 |
IUPHAR | 362 |
DrugBank | BE0002371 |
Name | CHEMBL567198 |
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Molecular formula | C27H34Cl3N3O2 |
IUPAC name | 4-[4-[acetyl(methyl)amino]piperidin-1-yl]-N-[(2-chlorophenyl)methyl]-2-(3,4-dichlorophenyl)-N,2-dimethylbutanamide |
Molecular weight | 538.938 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 5.5 |
Synonyms | SCHEMBL297642 4-[4-(acetylmethyl-amino)-piperidin-1-yl]-N-(2-chloro-benzyl)-2-(3,4-dichlorophenyl)-2,N-dimethylbutyramide BDBM50299470 |
Inchi Key | OZJDKUMSRQSURZ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H34Cl3N3O2/c1-19(34)32(4)22-11-14-33(15-12-22)16-13-27(2,21-9-10-24(29)25(30)17-21)26(35)31(3)18-20-7-5-6-8-23(20)28/h5-10,17,22H,11-16,18H2,1-4H3 |
PubChem CID | 44550460 |
ChEMBL | CHEMBL567198 |
IUPHAR | N/A |
BindingDB | 50299470 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kd | 18.2 nM | PMID19817444 | BindingDB,ChEMBL |
Ki | 10.4 nM | PMID19817444 | BindingDB,ChEMBL |
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