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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H4 receptor
Species	Homo sapiens (Human)
Gene	HRH4
Synonym	Pfi-013 SP9144 HH4R H4R H4 receptor GPRv53 GPCR105 G-protein coupled receptor 105 AXOR35 [ Show all ]
Disease	Allergic rhinitis Asthma Inflammatory disease Rheumatoid arthritis
Length	390
Amino acid sequence	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProt	Q9H3N8
Protein Data Bank	N/A
GPCR-HGmod model	Q9H3N8
3D structure model	This predicted structure model is from GPCR-EXP Q9H3N8.
BioLiP	N/A
Therapeutic Target Database	T26500
ChEMBL	CHEMBL3759
IUPHAR	265
DrugBank	BE0000146

Ligand

Name	Amselamine
Molecular formula	C6H11N3Se
IUPAC name	5-(2-aminoethyl)-4-methyl-1,3-selenazol-2-amine
Molecular weight	204.146
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	None
Synonyms	CHEMBL60686 5-(2-aminoethyl)-4-methyl-1,3-selenazol-2-amine 2-amino-5(2-aminoethyl)-4-methyl-1,3-selenazole CHEMBL1632408 BDBM22882
Inchi Key	PKGAPIBVLGICCE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H11N3Se/c1-4-5(2-3-7)10-6(8)9-4/h2-3,7H2,1H3,(H2,8,9)
PubChem CID	9990475
ChEMBL	CHEMBL1632408
IUPHAR	N/A
BindingDB	22882
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Intrinsic activity	0.0 -	PMID21044842	ChEMBL
Ki	2511.89 nM	PMID21044842	ChEMBL
Ki	2512.0 nM	PMID15947036	BindingDB

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