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Name | Alpha-2A adrenergic receptor |
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Species | Homo sapiens (Human) |
Gene | ADRA2A |
Synonym | alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A [ Show all ] |
Disease | Attention deficit hyperactivity disorder Sexual dysfunction Pain |
Length | 450 |
Amino acid sequence | MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV |
UniProt | P08913 |
Protein Data Bank | N/A |
GPCR-HGmod model | P08913 |
3D structure model | This predicted structure model is from GPCR-EXP P08913. |
BioLiP | N/A |
Therapeutic Target Database | T11448 |
ChEMBL | CHEMBL1867 |
IUPHAR | 25 |
DrugBank | BE0000289 |
Name | CHEMBL49137 |
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Molecular formula | C12H13N5 |
IUPAC name | N-(4,5-dihydro-1H-imidazol-2-yl)-5-methylquinoxalin-6-amine |
Molecular weight | 227.271 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 2 |
XlogP | 0.3 |
Synonyms | 91147-45-4 L005026 BDBM50052880 SCHEMBL15195137 DTXSID00238427 [ Show all ] |
Inchi Key | QZUXRMOPAGPTIY-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C12H13N5/c1-8-9(17-12-15-6-7-16-12)2-3-10-11(8)14-5-4-13-10/h2-5H,6-7H2,1H3,(H2,15,16,17) |
PubChem CID | 185076 |
ChEMBL | CHEMBL49137 |
IUPHAR | N/A |
BindingDB | 50052880 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 1.2 nM | N/A | BindingDB |
EC50 | 1.202 nM | Bioorg. Med. Chem. Lett., (1995) 5:19:2255 | ChEMBL |
Intrinsic activity | 1.0 - | Bioorg. Med. Chem. Lett., (1995) 5:19:2255 | ChEMBL |
Ki | 2.0 nM | PMID8784451, PMID9016324 | BindingDB,ChEMBL |
Ki | 7.2 nM | N/A | BindingDB |
Ki | 7.244 nM | Bioorg. Med. Chem. Lett., (1995) 5:19:2255 | ChEMBL |
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