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Name | Lysophosphatidic acid receptor 2 |
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Species | Homo sapiens (Human) |
Gene | LPAR2 |
Synonym | endothelial differentiation gene 4, lysophosphatidic acid G-protein-coupled receptor 4 LPA receptor 2 LPA-2 Edg4 Lysophosphatidic acid receptor Edg-4 [ Show all ] |
Disease | N/A |
Length | 351 |
Amino acid sequence | MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL |
UniProt | Q9HBW0 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9HBW0 |
3D structure model | This predicted structure model is from GPCR-EXP Q9HBW0. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3724 |
IUPHAR | 273 |
DrugBank | N/A |
Name | CHEMBL117798 |
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Molecular formula | C21H40NO4PS |
IUPAC name | (Z)-N-(3-dihydroxyphosphinothioyl-3-oxopropyl)octadec-9-enamide |
Molecular weight | 433.588 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | 6.6 |
Synonyms | BDBM50148349 (3-Octadec-9-enoylamino-propionyl)-phosphonothioic acid |
Inchi Key | RULDNVDOWBRXSL-KTKRTIGZSA-N |
Inchi ID | InChI=1S/C21H40NO4PS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)22-19-18-21(24)27(25,26)28/h9-10H,2-8,11-19H2,1H3,(H,22,23)(H2,25,26,28)/b10-9- |
PubChem CID | 44343866 |
ChEMBL | CHEMBL117798 |
IUPHAR | N/A |
BindingDB | 50148349 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 108.0 nM | PMID15177455 | BindingDB,ChEMBL |
Emax | 46.0 % | PMID15177455 | ChEMBL |
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