You can:
Name | D(2) dopamine receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | CHEMBL211539 |
---|---|
Molecular formula | C20H23BrN4O |
IUPAC name | 8-bromo-2-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-6-methylimidazo[1,2-a]pyridine |
Molecular weight | 415.335 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 4.3 |
Synonyms | 8-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-methylimidazo[1,2-a]pyridine BDBM50189851 |
Inchi Key | BSDZATNMASVMIK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C20H23BrN4O/c1-15-11-17(21)20-22-16(14-25(20)12-15)13-23-7-9-24(10-8-23)18-5-3-4-6-19(18)26-2/h3-6,11-12,14H,7-10,13H2,1-2H3 |
PubChem CID | 11661609 |
ChEMBL | CHEMBL211539 |
IUPHAR | N/A |
BindingDB | 50189851 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 150.0 nM | PMID16789750 | BindingDB,ChEMBL |
Ki | 240.0 nM | PMID16789750 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218