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Name | Melanocortin receptor 3 |
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Species | Homo sapiens (Human) |
Gene | MC3R |
Synonym | MC3-R melanocortin receptor 3 MC3 receptor gamma-MSH receptor |
Disease | Sexual dysfunction; Obesity; Type 2 diabetes |
Length | 323 |
Amino acid sequence | MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREILCGCNGMNLG |
UniProt | P41968 |
Protein Data Bank | N/A |
GPCR-HGmod model | P41968 |
3D structure model | This predicted structure model is from GPCR-EXP P41968. |
BioLiP | N/A |
Therapeutic Target Database | T76846 |
ChEMBL | CHEMBL4644 |
IUPHAR | 284 |
DrugBank | N/A |
Name | CHEMBL333283 |
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Molecular formula | C32H34ClN7O2 |
IUPAC name | (3R)-N-[(2R)-3-(4-chlorophenyl)-1-oxo-1-[4-[2-(1,2,4-triazol-4-ylmethyl)phenyl]piperazin-1-yl]propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide |
Molecular weight | 584.121 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 3.5 |
Synonyms | (R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid {(R)-1-(4-chloro-benzyl)-2-oxo-2-[4-(2-[1,2,4]triazol-4-ylmethyl-phenyl)-piperazin-1-yl]-ethyl}-amide (3R)-N-[(alphaR)-alpha-[4-[2-(4H-1,2,4-Triazole-4-ylmethyl)phenyl]piperazinocarbonyl]-4-chlorophenethyl]-1,2,3,4-tetrahydroisoquinoline-3beta-carboxamide BDBM50134488 |
Inchi Key | SQUPSEKHAYZJTP-FQLXRVMXSA-N |
Inchi ID | InChI=1S/C32H34ClN7O2/c33-27-11-9-23(10-12-27)17-29(37-31(41)28-18-24-5-1-2-6-25(24)19-34-28)32(42)40-15-13-39(14-16-40)30-8-4-3-7-26(30)20-38-21-35-36-22-38/h1-12,21-22,28-29,34H,13-20H2,(H,37,41)/t28-,29-/m1/s1 |
PubChem CID | 44349019 |
ChEMBL | CHEMBL333283 |
IUPHAR | N/A |
BindingDB | 50134488 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <3000.0 nM | PMID14552781 | BindingDB,ChEMBL |
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