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Name | 5-hydroxytryptamine receptor 6 |
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Species | Homo sapiens (Human) |
Gene | HTR6 |
Synonym | 5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 [ Show all ] |
Disease | Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis [ Show all ] |
Length | 440 |
Amino acid sequence | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN |
UniProt | P50406 |
Protein Data Bank | N/A |
GPCR-HGmod model | P50406 |
3D structure model | This predicted structure model is from GPCR-EXP P50406. |
BioLiP | N/A |
Therapeutic Target Database | T16691 |
ChEMBL | CHEMBL3371 |
IUPHAR | 11 |
DrugBank | BE0000945 |
Name | mianserin |
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Molecular formula | C18H20N2 |
IUPAC name | 5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene |
Molecular weight | 264.372 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 0 |
XlogP | 3.4 |
Synonyms | Mianserin [INN:BAN] Mianseryna [Polish] 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine # NCGC00024926-03 AC1L1HLP [ Show all ] |
Inchi Key | UEQUQVLFIPOEMF-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3 |
PubChem CID | 4184 |
ChEMBL | CHEMBL6437 |
IUPHAR | 135 |
BindingDB | N/A |
DrugBank | DB06148 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
IC50 | 85.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Ki | 40.0 nM | DrugMatrix in vitro pharmacology data | ChEMBL |
Ki | 50.1187 - 125.893 nM | PMID8522988, PMID9730917, PMID9284367 | IUPHAR |
Ki | 55.0 nM | PMID8522988, PMID12825922 | PDSP,ChEMBL |
Ki | 81.2831 nM | PMID14645659 | PDSP |
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