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Name | D(4) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD4 |
Synonym | D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor |
Disease | Erectile dysfunction Psychotic disorders Schizophrenia |
Length | 467 |
Amino acid sequence | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC |
UniProt | P21917 |
Protein Data Bank | 5wiv, 5wiu |
GPCR-HGmod model | P21917 |
3D structure model | This structure is from PDB ID 5wiv. |
BioLiP | BL0394824, BL0394826, BL0394825 |
Therapeutic Target Database | T24983 |
ChEMBL | CHEMBL219 |
IUPHAR | 217 |
DrugBank | BE0009376, BE0000389 |
Name | CHEMBL28321 |
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Molecular formula | C22H25N3O |
IUPAC name | 1-(2-methoxyphenyl)-4-[(1-phenylpyrrol-3-yl)methyl]piperazine |
Molecular weight | 347.462 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 3.7 |
Synonyms | 1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmethyl)-piperazine BDBM50048233 1-Phenyl-3-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-1H-pyrrole |
Inchi Key | UPXJKNQVKALXKP-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H25N3O/c1-26-22-10-6-5-9-21(22)24-15-13-23(14-16-24)17-19-11-12-25(18-19)20-7-3-2-4-8-20/h2-12,18H,13-17H2,1H3 |
PubChem CID | 10450375 |
ChEMBL | CHEMBL28321 |
IUPHAR | N/A |
BindingDB | 50048233 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.7 nM | PMID9822559 | BindingDB,ChEMBL |
Ki | 1.3 nM | , Bioorg. Med. Chem. Lett., (1997) 7:10:1327, PMID8523409 | BindingDB,ChEMBL |
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