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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Somatostatin receptor type 2
Species	Homo sapiens (Human)
Gene	SSTR2
Synonym	somatotropin release-inhibiting factor receptor SRIF-1 SS-2-R SS2-R SS2R SST2 receptor [ Show all ]
Disease	Acromegaly Lung cancer Neuroendocrine cancer
Length	369
Amino acid sequence	MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
UniProt	P30874
Protein Data Bank	N/A
GPCR-HGmod model	P30874
3D structure model	This predicted structure model is from GPCR-EXP P30874.
BioLiP	N/A
Therapeutic Target Database	T53024
ChEMBL	CHEMBL1804
IUPHAR	356
DrugBank	BE0003528

Ligand

Name	CHEMBL426072
Molecular formula	C25H25N5S
IUPAC name	3-[3-[2-(1H-indol-3-yl)ethylsulfanyl]-5-naphthalen-2-yl-1,2,4-triazol-4-yl]propan-1-amine
Molecular weight	427.57
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	4.6
Synonyms	BDBM50169479 SCHEMBL3811918 3-{3-[2-(1H-Indol-3-yl)-ethylsulfanyl]-5-naphthalen-2-yl-[1,2,4]triazol-4-yl}-propylamine
Inchi Key	BWXQCLKEXFOZQZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H25N5S/c26-13-5-14-30-24(20-11-10-18-6-1-2-7-19(18)16-20)28-29-25(30)31-15-12-21-17-27-23-9-4-3-8-22(21)23/h1-4,6-11,16-17,27H,5,12-15,26H2
PubChem CID	44397834
ChEMBL	CHEMBL426072
IUPHAR	N/A
BindingDB	50169479
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	640.0 nM	PMID15982879	BindingDB,ChEMBL

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