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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H4 receptor
Species	Mus musculus (Mouse)
Gene	Hrh4
Synonym	GPCR105 H4 receptor H4R HH4R
Disease	N/A for non-human GPCRs
Length	391
Amino acid sequence	MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
UniProt	Q91ZY2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5657
IUPHAR	265
DrugBank	N/A

Ligand

Name	CHEMBL3236553
Molecular formula	C13H21N5
IUPAC name	4-cyclopentyl-6-piperazin-1-ylpyrimidin-2-amine
Molecular weight	247.346
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	1.3
Synonyms	SCHEMBL604826 4-Cyclopentyl-6-piperazin-1-yl-pyrimidin-2-ylamine 1013105-41-3 UYXWQSZIUMRFIW-UHFFFAOYSA-N 4-cyclopentyl-6-(piperazin-1-yl)-pyrimidin-2-ylamine BDBM50006742 [ Show all ]
Inchi Key	UYXWQSZIUMRFIW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H21N5/c14-13-16-11(10-3-1-2-4-10)9-12(17-13)18-7-5-15-6-8-18/h9-10,15H,1-8H2,(H2,14,16,17)
PubChem CID	24798144
ChEMBL	CHEMBL3236553
IUPHAR	N/A
BindingDB	50006742
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	7.3 nM	PMID24495018	BindingDB,ChEMBL
Kd	10.0 nM	PMID24495018	ChEMBL
Ki	20.0 nM	PMID24495018	BindingDB,ChEMBL

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