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GLASS

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GPCR

Name	Metabotropic glutamate receptor 2
Species	Rattus norvegicus (Rat)
Gene	Grm2
Synonym	glutamate receptor GPRC1B metabotropic glutamate receptor 2 mGlu2 receptor mGluR2
Disease	N/A for non-human GPCRs
Length	872
Amino acid sequence	MESLLGFLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHSDAPTAVTGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEERFHCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTHLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSFIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFVFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProt	P31421
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2851
IUPHAR	290
DrugBank	N/A

Ligand

Name	CHEMBL144201
Molecular formula	C8H9F2NO4
IUPAC name	(1S,2S,5R,6S)-2-amino-3,3-difluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Molecular weight	221.16
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	-2.9
Synonyms	(+/-)-2-Amino-3,3-difluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid BDBM50094847
Inchi Key	BYEDBNFXHDLGBU-NHDVCMSYSA-N
Inchi ID	InChI=1S/C8H9F2NO4/c9-7(10)1-2-3(5(12)13)4(2)8(7,11)6(14)15/h2-4H,1,11H2,(H,12,13)(H,14,15)/t2-,3-,4-,8-/m0/s1
PubChem CID	10176836
ChEMBL	CHEMBL144201
IUPHAR	N/A
BindingDB	50094847
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<100000.0 nM	PMID11123999	ChEMBL
EC50	36200.0 nM	PMID11123999	ChEMBL

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