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Name | Neuromedin-K receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Tacr3 |
Synonym | Tac3r SP-N receptor Nmkr NKR NK3 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 452 |
Amino acid sequence | MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDEYS |
UniProt | P16177 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3154 |
IUPHAR | 362 |
DrugBank | N/A |
Name | CHEMBL47146 |
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Molecular formula | C29H41FN4O4 |
IUPAC name | [(1S)-2-methyl-1-phenylpropyl] N-[(2R)-1-[7-(carbamoylamino)heptylamino]-3-(2-fluorophenyl)-2-methyl-1-oxopropan-2-yl]carbamate |
Molecular weight | 528.669 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 4 |
XlogP | 5.1 |
Synonyms | PD-160946 [(R)-2-(2-Fluoro-phenyl)-1-methyl-1-(7-ureido-heptylcarbamoyl)-ethyl]-carbamic acid (S)-2-methyl-1-phenyl-propyl ester BDBM50050652 D0J3AO |
Inchi Key | ZAYADERDILOEBG-ABYGYWHVSA-N |
Inchi ID | InChI=1S/C29H41FN4O4/c1-21(2)25(22-14-8-7-9-15-22)38-28(37)34-29(3,20-23-16-10-11-17-24(23)30)26(35)32-18-12-5-4-6-13-19-33-27(31)36/h7-11,14-17,21,25H,4-6,12-13,18-20H2,1-3H3,(H,32,35)(H,34,37)(H3,31,33,36)/t25-,29+/m0/s1 |
PubChem CID | 9914897 |
ChEMBL | CHEMBL47146 |
IUPHAR | N/A |
BindingDB | 50050652 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 83.0 nM | PMID8648606 | BindingDB,ChEMBL |
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