You can:
Name | Prostacyclin receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | PTGIR |
Synonym | prostanoid IP receptor prostaglandin I2 receptor prostaglandin I2 (prostacyclin) receptor (IP) prostacyclin receptor PGI2 receptor [ Show all ] |
Disease | Solid tumours Pulmonary hypertension Medical abortion Pulmonary arterial hypertension Hypertension [ Show all ] |
Length | 386 |
Amino acid sequence | MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC |
UniProt | P43119 |
Protein Data Bank | N/A |
GPCR-HGmod model | P43119 |
3D structure model | This predicted structure model is from GPCR-EXP P43119. |
BioLiP | N/A |
Therapeutic Target Database | T99954 |
ChEMBL | CHEMBL1995 |
IUPHAR | 345 |
DrugBank | BE0000475 |
Name | CHEMBL3398228 |
---|---|
Molecular formula | C29H24F2N2O4 |
IUPAC name | 2-[[6-[[4-(2,3-difluorophenyl)-6-oxo-5-phenylpyridazin-1-yl]methyl]-5,6,7,8-tetrahydronaphthalen-1-yl]oxy]acetic acid |
Molecular weight | 502.518 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 5.1 |
Synonyms | BDBM50103404 |
Inchi Key | CQMKTKJCIXXKCC-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C29H24F2N2O4/c30-24-10-5-9-22(28(24)31)23-15-32-33(29(36)27(23)19-6-2-1-3-7-19)16-18-12-13-21-20(14-18)8-4-11-25(21)37-17-26(34)35/h1-11,15,18H,12-14,16-17H2,(H,34,35) |
PubChem CID | 118727307 |
ChEMBL | CHEMBL3398228 |
IUPHAR | N/A |
BindingDB | 50103404 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 38.0 nM | PMID25666818 | BindingDB,ChEMBL |
IC50 | 87.0 nM | PMID25666818 | BindingDB,ChEMBL |
Intrinsic activity | 87.0 % | PMID25666818 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218