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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor homolog US28
Species	Human cytomegalovirus (strain AD169) (HHV-5)
Gene	US28
Synonym	HHRF3
Disease	N/A for non-human GPCRs
Length	354
Amino acid sequence	MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
UniProt	P69332
Protein Data Bank	4xt1
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4xt1.
BioLiP	BL0309402,BL0309403
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4259
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL1824275
Molecular formula	C27H27NO3
IUPAC name	[3-methyl-2-(2-phenylacetyl)-1,4-dihydroisoquinolin-3-yl]methyl 2-phenylacetate
Molecular weight	413.517
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.6
Synonyms	SCHEMBL16948652
Inchi Key	YPOSMQPBVIXZBM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H27NO3/c1-27(20-31-26(30)17-22-12-6-3-7-13-22)18-23-14-8-9-15-24(23)19-28(27)25(29)16-21-10-4-2-5-11-21/h2-15H,16-20H2,1H3
PubChem CID	56682429
ChEMBL	CHEMBL1824275
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3400.0 nM	PMID25052428	ChEMBL
EC50	3467.37 nM	PMID25052428	ChEMBL
Efficacy	-37.0 %	PMID25052428	ChEMBL

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