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Name | D(3) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD3 |
Synonym | dopaminergic receptor D3 D3R D3 receptor dopamine D3 receptor |
Disease | Unspecified Emesis; Gastric motility disorder Female sexual dysfunction Male sexual disorders Psychotic disorders [ Show all ] |
Length | 400 |
Amino acid sequence | MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC |
UniProt | P35462 |
Protein Data Bank | 3pbl |
GPCR-HGmod model | P35462 |
3D structure model | This structure is from PDB ID 3pbl. |
BioLiP | BL0191566, BL0191567 |
Therapeutic Target Database | T02551 |
ChEMBL | CHEMBL234 |
IUPHAR | 216 |
DrugBank | BE0000581 |
Name | fauc-365 |
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Molecular formula | C23H25Cl2N3OS |
IUPAC name | N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-1-benzothiophene-2-carboxamide |
Molecular weight | 462.433 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 6.2 |
Synonyms | BDBM50119390 N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)benzo[b]thiophene-2-carboxamide ZINC13491634 AOB1711 KB-272558 [ Show all ] |
Inchi Key | CPTSTFKVXWZGEV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H25Cl2N3OS/c24-18-7-5-8-19(22(18)25)28-14-12-27(13-15-28)11-4-3-10-26-23(29)21-16-17-6-1-2-9-20(17)30-21/h1-2,5-9,16H,3-4,10-15H2,(H,26,29) |
PubChem CID | 10276451 |
ChEMBL | CHEMBL59725 |
IUPHAR | N/A |
BindingDB | 50119390 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 4.9 - | PMID15689168 | ChEMBL |
IC50 | 4.94 nM | PMID19331412, PMID15916415 | BindingDB,ChEMBL |
Ki | 0.5 nM | PMID15225707, PMID16139501, PMID15689154, PMID23618707, PMID15916415, PMID21273071, PMID12361386 | BindingDB,ChEMBL |
Ki | 0.5012 nM | PMID17266201 | ChEMBL |
Ki | 0.8 nM | PMID15916415, PMID15689168 | BindingDB,ChEMBL |
Ki | 0.81 nM | PMID19331412 | BindingDB,ChEMBL |
Ki | 2.6 nM | PMID15916415 | BindingDB,ChEMBL |
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