You can:
Name | G-protein coupled receptor 55 |
---|---|
Species | Homo sapiens (Human) |
Gene | GPR55 |
Synonym | GPR55 |
Disease | N/A |
Length | 319 |
Amino acid sequence | MSQQNTSGDCLFDGVNELMKTLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNIRAHRPSRVQLVLQDTTISRG |
UniProt | Q9Y2T6 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9Y2T6 |
3D structure model | This predicted structure model is from GPCR-EXP Q9Y2T6. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1075322 |
IUPHAR | 109 |
DrugBank | BE0005802 |
Name | CHEMBL3779954 |
---|---|
Molecular formula | C27H32N4O4 |
IUPAC name | 1-[4-[2-(7-methoxy-4,4-dimethylchromeno[4,3-c]pyrazol-2-yl)ethyl]piperazin-1-yl]-2-phenoxyethanone |
Molecular weight | 476.577 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 0 |
XlogP | 2.9 |
Synonyms | BDBM50156106 |
Inchi Key | BDZJIXFHXRVQQJ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H32N4O4/c1-27(2)23-18-31(28-26(23)22-10-9-21(33-3)17-24(22)35-27)16-13-29-11-14-30(15-12-29)25(32)19-34-20-7-5-4-6-8-20/h4-10,17-18H,11-16,19H2,1-3H3 |
PubChem CID | 127030160 |
ChEMBL | CHEMBL3779954 |
IUPHAR | N/A |
BindingDB | 50156106 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 1.28 nM | PMID26789378 | ChEMBL |
EC50 | 1.3 nM | PMID26789378 | BindingDB |
EC50 | 18.0 nM | PMID26789378 | BindingDB |
EC50 | 18.2 nM | PMID26789378 | ChEMBL |
Emax | 52.0 % | PMID26789378 | ChEMBL |
Emax | 100.0 % | PMID26789378 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218