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Name | Motilin receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | MLNR |
Synonym | GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR [ Show all ] |
Disease | Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder [ Show all ] |
Length | 412 |
Amino acid sequence | MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG |
UniProt | O43193 |
Protein Data Bank | N/A |
GPCR-HGmod model | O43193 |
3D structure model | This predicted structure model is from GPCR-EXP O43193. |
BioLiP | N/A |
Therapeutic Target Database | T62306 |
ChEMBL | CHEMBL2203 |
IUPHAR | 297 |
DrugBank | BE0003521 |
Name | CHEMBL473921 |
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Molecular formula | C30H36FN5O |
IUPAC name | [3-[4-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]pyridin-2-yl]-[4-(4-fluoroanilino)piperidin-1-yl]methanone |
Molecular weight | 501.65 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 2 |
XlogP | 4.7 |
Synonyms | BDBM50247157 SCHEMBL4700720 (3-(4-(((3R,5S)-3,5-dimethylpiperazin-1-yl)methyl)phenyl)pyridin-2-yl)(4-(4-fluorophenylamino)piperidin-1-yl)methanone {3-[4-((3R,5S)-3,5-Dimethyl-piperazin-1-ylmethyl)-phenyl]-pyridin-2-yl}-[4-(4-fluoro-phenylamino)-piperidin-1-yl]-methanone |
Inchi Key | CYEIOVYZTVJICS-SZPZYZBQSA-N |
Inchi ID | InChI=1S/C30H36FN5O/c1-21-18-35(19-22(2)33-21)20-23-5-7-24(8-6-23)28-4-3-15-32-29(28)30(37)36-16-13-27(14-17-36)34-26-11-9-25(31)10-12-26/h3-12,15,21-22,27,33-34H,13-14,16-20H2,1-2H3/t21-,22+ |
PubChem CID | 16040587 |
ChEMBL | CHEMBL473921 |
IUPHAR | N/A |
BindingDB | 50247157 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 3.98 nM | PMID19191554 | BindingDB |
EC50 | 3.981 nM | PMID19191554 | ChEMBL |
EC50 | 19.95 nM | PMID19006669 | BindingDB,ChEMBL |
IC50 | 3.981 nM | PMID23281966 | ChEMBL |
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