You can:
Name | Metabotropic glutamate receptor 2 |
---|---|
Species | Homo sapiens (Human) |
Gene | GRM2 |
Synonym | mGluR2 mGlu2 receptor metabotropic glutamate receptor 2 GPRC1B glutamate receptor |
Disease | Central nervous system disease Anxiety disorder Bipolar disorder Major depressive disorder Mood disorder [ Show all ] |
Length | 872 |
Amino acid sequence | MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL |
UniProt | Q14416 |
Protein Data Bank | 5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq |
GPCR-HGmod model | N/A |
3D structure model | This structure is from PDB ID 5cnj. |
BioLiP | BL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443 |
Therapeutic Target Database | T62820 |
ChEMBL | CHEMBL5137 |
IUPHAR | 290 |
DrugBank | N/A |
Name | CHEMBL3973048 |
---|---|
Molecular formula | C22H16F3N5O4 |
IUPAC name | 1-[2-hydroxy-4-[[3-[5-(2H-tetrazol-5-yl)pyridin-2-yl]oxyphenyl]methoxy]-3-(trifluoromethyl)phenyl]ethanone |
Molecular weight | 471.396 |
Hydrogen bond acceptor | 11 |
Hydrogen bond donor | 2 |
XlogP | 4.2 |
Synonyms | BDBM50207411 SCHEMBL3171343 |
Inchi Key | CKZVZHCCDNZZSV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H16F3N5O4/c1-12(31)16-6-7-17(19(20(16)32)22(23,24)25)33-11-13-3-2-4-15(9-13)34-18-8-5-14(10-26-18)21-27-29-30-28-21/h2-10,32H,11H2,1H3,(H,27,28,29,30) |
PubChem CID | 59599580 |
ChEMBL | CHEMBL3973048 |
IUPHAR | N/A |
BindingDB | 50207411 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 17.9 nM | PMID27908761 | ChEMBL |
EC50 | 18.0 nM | PMID27908761 | BindingDB |
Emax | 85.0 % | PMID27908761 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218