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GLASS

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GPCR

Name	Gamma-aminobutyric acid type B receptor subunit 2
Species	Homo sapiens (Human)
Gene	GABBR2
Synonym	HG20 GPRC3B GPR51 Gb2 gamma-aminobutyric acid (GABA) B receptor, 2 gamma-aminobutyric acid (GABA) B receptor 2 gamma-aminobutyric acid (GABA) B receptor GABABR2 GABAB2 GABA-BR2 GABA-B-R2 GABA-B R2 receptor G-protein coupled receptor 51 G protein-coupled receptor 51 GABA-B receptor 2 [ Show all ]
Disease	Pain Drug abuse Fragile X syndrome Nicotine dependence Partial seizures Depression Cancer Schizophrenia Absence seizures Anxiety disorder [ Show all ]
Length	941
Amino acid sequence	MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL
UniProt	O75899
Protein Data Bank	4mr7, 4mr8
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4mr7.
BioLiP	BL0264360, BL0264364, BL0264363, BL0264362, BL0264361
Therapeutic Target Database	T42446
ChEMBL	N/A
IUPHAR	N/A
DrugBank	BE0002340

Ligand

Name	4-aminobutyric acid
Molecular formula	C4H9NO2
IUPAC name	4-aminobutanoic acid
Molecular weight	103.121
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	-3.2
Synonyms	178648-EP2269992A1 CHEMBL96 3131-86-0 4-amino-n-butyric acid DTXSID6035106 4-Aminobutyric acid, 99+% Gaballon A 2129 GAMMA-AMINO-BUTANOIC ACID Acide amino-4- butyrique [French] gamma-aminobutyric acid Aminalone Gamma-Aminobutyric Acid,(S) BDBM24183 BSPBio_002970 13511-EP2272537A2 Butyric acid, 4-amino- (7CI,8CI) KBio2_000429 SR-01000075618-1 KSC269S7N TL8006100 MCULE-7613134021 UNII-2ACZ6IPC6I NCGC00015043-03 [3H]GABA NCGC00024546-01 NINDS_000616 NSC32044 PDSP1_001275 Globulin, immune human serum RTR-019733 I04-0182 SPBio_000996 178648-EP2277865A1 CS-W020704 33777-EP2311453A1 DivK1c_000616 4-Aminobutanoic acid EU-0100005 4Abu Gamastan AB00052155_12 gamma-Aminobutryic acid AJ-26795 gamma-Aminobutyric acid, >=99% AN-24434 Gammalon (TN) bmse000820 .gamma.-Aminobutanoic acid Butanoic acid, 4-amino- (9CI) 13511-EP2298766A1 CAS-56-12-2 Spectrum3_001385 KBio3_002190 SR-01000075618-7 Lopac-A-2129 Tox21_110071 Mielomade w-Aminobutyrate NCGC00015043-06 NCGC00024546-04 NSC-32044 NSC757426 Piperidic acid GTPL5410 SBI-0049994.P003 Immu-G CHEBI:16865 2ACZ6IPC6I D0C9XA 4-AMINO-BUTYRATE DSSTox_GSID_35106 4-Aminobutyric g-Aminobutyric acid 6610-05-5 (mono-hydrochloride salt) GAMMA(AMINO)-BUTYRIC ACID AC1Q54DP gamma-Aminobuttersaure AM20100372 gamma-Aminobutyric acid, certified reference material, TraceCERT(R) BBL008590 BR-43987 Butanoicacid, 4-amino- 13511-EP2314571A2 KB-62456 Spectrum_000049 KS-000048O9 STK301748 LS-47805 TR-019733 NCGC00015043-01 Z955123658 NCGC00015043-09 NCGC00260690-01 NSC-757426 Opera_ID_1152 Gammasol Reanal HMS3260A11 SGCUT00121 178648-EP2270002A1 Chemical Name: .gamma.-Aminobutanoic acid 33777-EP2286811A1 DB02530 4-amino-n-[2,3-3H]butyric acid EINECS 200-258-6 4-NH2-but gam.-Aminobutyric acid a-Aminobutyric acid gamma-amino-n-butyric acid ACMC-1CAQ1 gamma-Aminobutyric acid (JAN) Aminobutanoic acid Gammagee Biomol-NT_000230 .gamma.-Amino-butyric acid BTCSSZJGUNDROE-UHFFFAOYSA-N 13511-EP2275401A1 C00334 KBio2_002997 SR-01000075618-3 L000262 TL806167 MFCD00008226 Vigabatrin EP Impurity D NCGC00015043-04 NCGC00024546-02 NSC 27418 NSC45460 PDSP2_001259 GSK683699 s4700 I04-1117 SPECTRUM1500678 CCG-38515 20-79-1 CTK1G9976 4-amino butyric acid DL-gamma-AMINO-n-BUTYRIC ACID 4-Aminobutylate F2191-0196 56-12-2 Gamma aminobutyrate AB1003088 gamma-Aminobuttersaeure AK-43987 gamma-Aminobutyric acid, analytical standard ANW-13573 bmse000871 .gamma.-Aminobutyric acid BUTANOIC ACID,4-AMINO 13511-EP2298776A1 Spectrum4_000809 KBioGR_001297 ST2411110 Lopac0_000005 Tox21_500005 MLS000028505 w-Aminobutyric acid NCGC00015043-07 NCGC00024546-05 NSC-45460 omega-Aminobutyrate Gammalone Piperidinate HMS1921C06 SC-10045 Immuglobin 3-Carboxypropylamine D0D3ID 4-Amino-butyric acid DSSTox_RID_79238 GABA 70582-09-1 (calcium salt (2:1)) gamma-Amino butyric acid Acide amino-4- butyrique gamma-aminobutyrate Aminalon gamma-Aminobutyric acid, United States Pharmacopeia (USP) Reference Standard BC204189 BRD-K77245796-001-19-2 13511-EP2269989A1 Butyric acid, 4-amino- 13511-EP2316836A1 KBio1_000616 SR-01000075618 KS-5273 STR01523 M-7233 TRA0094659 NCGC00015043-02 ZINC1532620 NCGC00015043-10 NH2-(CH2)3-COOH NSC27418 Oprea1_584567 Gamulin RP18806 HMS501O18 SMR000058285 178648-EP2275102A1 cid_119 33777-EP2295055A2 DF 468 4-aminobutanoate EPA Pesticide Chemical Code 030802 4-NH3-but Gamarex A0282 gamma-Aminobutanoic acid AI3-26812 Gamma-aminobutyric acid [JAN] Aminobutyric acid,-4- Gammalon bmse000340 .gamma.-Amino-N-butyric acid butanoic acid, 4-amino- 13511-EP2292222A1 C5C3DC27-C105-4D18-8A52-F51978B32D24 Spectrum2_001208 KBio2_005565 SR-01000075618-6 LMFA01100039 Tocris-0344 Mielogen Vigabatrin impurity D, European Pharmacopoeia (EP) Reference Standard NCGC00015043-05 NCGC00024546-03 NSC-27418 NSC51295 Pharmakon1600-01500678 GTPL1067 SBB028179 IDI1_000616 CCRIS 3721 D00058 4-amino-butanoic acid DSSTox_CID_15106 4-aminobutyrate FT-0617569 5959-35-3 (hydrochloride) gamma Aminobutyric acid AC1L18IR gamma-Aminobuttersaeure [German] AKOS000119660 gamma-Aminobutyric acid, BioXtra, >=99% ARONIS27190 BP-21452 .omega.-Aminobutyric acid BUTANOIC ACID,4-AMINO 4-AMINO,BUTYRIC ACID 13511-EP2308875A1 Spectrum5_001425 KBioSS_000429 ST45061580 LP00005 to_000021 MolPort-000-146-216 WLN: Z3VQ NCGC00015043-08 NCGC00024546-06 NSC-51295 omega-Aminobutyric acid Gammar Piperidinic acid HMS2232P09 SCHEMBL4878 InChI=1/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7 [ Show all ]
Inchi Key	BTCSSZJGUNDROE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
PubChem CID	119
ChEMBL	CHEMBL96
IUPHAR	1067
BindingDB	24183
DrugBank	DB02530
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank

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